Document Detail

Identification and specificity of pilus adsorption proteins of filamentous bacteriophages infecting Pseudomonas aeruginosa.
MedLine Citation:
PMID:  16298408     Owner:  NLM     Status:  MEDLINE    
Filamentous bacteriophages Pf1 and Pf3 infect Pseudomonas aeruginosa strains K and O, respectively. We show here that the capsids of these bacteriophages each contain a few copies of a minor coat protein (designated g3p) of high molecular mass, which serves as a pilus adsorption protein, much like the protein g3p of the Ff bacteriophages which infect Escherichia coli. Bacteriophage Pf1 was observed to interact with the type IV PAK pilus whereas bacteriophage Pf3 interacted with the conjugative RP4 pilus and not with the type IV PAO pilus. The specificity was found to be mediated by their pilus-binding proteins. This is evidence of a conserved pathway of infection among different classes of filamentous bacteriophage. However, there are likely to be subtle differences yet to be discovered in the way these virions effect entry into their targeted bacterial cells.
Samantha J Holland; Carolina Sanz; Richard N Perham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-18
Journal Detail:
Title:  Virology     Volume:  345     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-03-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  540-8     Citation Subset:  IM    
Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
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MeSH Terms
Amino Acid Sequence
Capsid Proteins
DNA-Binding Proteins / chemistry,  genetics,  metabolism
Fimbriae, Bacterial / virology*
Inovirus / genetics,  metabolism,  physiology*
Molecular Sequence Data
Open Reading Frames / genetics
Pseudomonas aeruginosa / virology*
Viral Fusion Proteins / chemistry,  genetics,  metabolism
Viral Proteins* / chemistry,  genetics,  metabolism
Virion / pathogenicity
Reg. No./Substance:
0/Capsid Proteins; 0/DNA-Binding Proteins; 0/Viral Fusion Proteins; 0/Viral Proteins

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