Document Detail


Identification of six CAG repeat domains into the human chromosomic region 12q24.1.
MedLine Citation:
PMID:  10799327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Six different domains of CAG repeats from a human chromosome 12 specific cosmid library were identified, cloned, and sequenced. These CAG repeat domains were localized into the human chromosomic region 12q24.1. Five of them constitute repeat candidates for expansions in autosomal dominant neurological disorders with genetic anticipation, and they can also contribute to the chromosome walking in the human genome project.
Authors:
J Aguiar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  271     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-13     Completed Date:  2000-06-13     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-7     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Division of Pharmaceutics, Center for Genetic Engineering and Biotechnology, Cubanacan, Havana City, C.P 10600, Cuba. Jorge.Aguiar@cigb.cu
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AJ131893;  AJ131894;  AJ131895;  AJ131896;  AJ131897;  AJ131898
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MeSH Terms
Descriptor/Qualifier:
Anticipation, Genetic
Base Sequence
Blotting, Southern
Chromosome Mapping
Chromosomes, Human, Pair 12*
Cloning, Molecular
Cosmids
Gene Library
Humans
Molecular Sequence Data
Muscular Atrophy, Spinal / genetics
Nucleic Acid Hybridization
Trinucleotide Repeats*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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