| Identification and significance of phenazone drugs and their metabolites in ground- and drinking water. | |
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MedLine Citation:
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PMID: 12430641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Residues of three phenazone-type pharmaceuticals have been identified in routine analyses of groundwater samples from selected areas in the north-western districts of Berlin, Germany. Phenazone, propiphenazone, and dimethylaminophenazone have been detected in some wells at concentrations up to the low microg/l-level. Additionally, three phenazone-type metabolites namely 1-acetyl-1-methyl-2-dimethyl-oxamoyl-2-phenylhydrazide (AMDOPH), 1-acetyl-1-methyl-2-phenylhydrazide, and dimethyloxalamide acid-(N'-methyl-N-phenyl)-hydrazide have also been identified in these groundwater samples. The residues are suspected to originate from former production spills of a pharmaceutical plant located in a city north of Berlin. It was observed that with the exception of AMDOPH all other residues were efficiently removed during conventional drinking water treatment. The drug metabolite AMDOPH deriving from dimethylaminophenazone residues was found at concentrations of 0.9 microg/l in finished drinking water. However, a following study on the toxicological relevance of the AMDOPH residues has shown that there is no toxicological harm for humans at the low concentrations of AMDOPH observed in Berlin drinking water. |
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Authors:
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Kirsten Reddersen; Thomas Heberer; Uwe Dünnbier |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemosphere Volume: 49 ISSN: 0045-6535 ISO Abbreviation: Chemosphere Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-14 Completed Date: 2003-04-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: England |
Other Details:
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Languages: eng Pagination: 539-44 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antipyrine
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analogs & derivatives*,
isolation & purification*,
metabolism Chromatography / methods Drug Residues / analysis* Environmental Monitoring / methods* Filtration Humans Phenylhydrazines / chemistry, isolation & purification Spectrometry, Mass, Electrospray Ionization Toxicity Tests Water Pollutants, Chemical / analysis, isolation & purification* Water Supply* |
| Chemical | |
Reg. No./Substance:
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0/Phenylhydrazines; 0/Water Pollutants, Chemical; 60-80-0/Antipyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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