Document Detail


Identification and significance of phenazone drugs and their metabolites in ground- and drinking water.
MedLine Citation:
PMID:  12430641     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Residues of three phenazone-type pharmaceuticals have been identified in routine analyses of groundwater samples from selected areas in the north-western districts of Berlin, Germany. Phenazone, propiphenazone, and dimethylaminophenazone have been detected in some wells at concentrations up to the low microg/l-level. Additionally, three phenazone-type metabolites namely 1-acetyl-1-methyl-2-dimethyl-oxamoyl-2-phenylhydrazide (AMDOPH), 1-acetyl-1-methyl-2-phenylhydrazide, and dimethyloxalamide acid-(N'-methyl-N-phenyl)-hydrazide have also been identified in these groundwater samples. The residues are suspected to originate from former production spills of a pharmaceutical plant located in a city north of Berlin. It was observed that with the exception of AMDOPH all other residues were efficiently removed during conventional drinking water treatment. The drug metabolite AMDOPH deriving from dimethylaminophenazone residues was found at concentrations of 0.9 microg/l in finished drinking water. However, a following study on the toxicological relevance of the AMDOPH residues has shown that there is no toxicological harm for humans at the low concentrations of AMDOPH observed in Berlin drinking water.
Authors:
Kirsten Reddersen; Thomas Heberer; Uwe Dünnbier
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemosphere     Volume:  49     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-14     Completed Date:  2003-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  539-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antipyrine / analogs & derivatives*,  isolation & purification*,  metabolism
Chromatography / methods
Drug Residues / analysis*
Environmental Monitoring / methods*
Filtration
Humans
Phenylhydrazines / chemistry,  isolation & purification
Spectrometry, Mass, Electrospray Ionization
Toxicity Tests
Water Pollutants, Chemical / analysis,  isolation & purification*
Water Supply*
Chemical
Reg. No./Substance:
0/Phenylhydrazines; 0/Water Pollutants, Chemical; 60-80-0/Antipyrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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