Document Detail

Identification of severe coronary artery disease using simple clinical parameters.
MedLine Citation:
PMID:  1739359     Owner:  NLM     Status:  MEDLINE    
The purpose of our study was to examine the ability of clinical and resting electrocardiographic variables to provide useful estimates of the probability of three-vessel or left-main coronary artery disease. The study group consisted of 680 patients with symptomatic coronary artery disease who underwent exercise equilibrium radionuclide angiography and coronary angiography within 6 months. Sixteen clinical and electrocardiographic variables were examined by logistic regression analysis. The independently predictive variables were then used to develop convenient graphic estimates of the probability of three-vessel or left-main disease and to classify patients into high-risk (greater than 35%), intermediate-risk (15-35%), or low-risk (less than 15%) groups. Five variables were independently predictive of left-main or three-vessel disease: age, typical angina, diabetes, gender, and both history and electrocardiographic evidence of a prior myocardial infarction. A single graph was constructed that displayed the probability of severe coronary artery disease as a function of a five-point cardiac risk scale, which incorporated these variables. Two hundred sixty-two patients (39% of the study group) were classified as high risk; 127 of these patients (48%) had three-vessel or left-main disease. An additional 96 patients were classified as low risk; nine of these patients (9%) had three-vessel or left-main disease. Five clinical variables that were obtained on an initial patient assessment can provide useful estimates of the likelihood of severe coronary disease.
B L Hubbard; R J Gibbons; A C Lapeyre; A R Zinsmeister; I P Clements
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  152     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-19     Completed Date:  1992-03-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  309-12     Citation Subset:  AIM; IM    
Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
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MeSH Terms
Coronary Angiography
Coronary Disease / diagnosis*,  radiography,  radionuclide imaging
Heart / radionuclide imaging
Middle Aged
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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