| Identification of serum biomarkers for lung cancer using protein mass spectrometry. | |
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MedLine Citation:
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PMID: 22710637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prior to pathological changes becoming apparent in any disease, the component and amount of intracellular proteins may undergo alteration. Thus, monitoring of proteins may be used to screen indicators in order to identify prognostic markers. The aim of this study was to investigate the feasibility of identification of serum biomarkers for lung cancer using protein mass spectrometry. Surface-enhanced laser desorption/ionization (SELDI) and weak cation exchange 2 (WCX2) protein chip array were employed for protein profiling of the sera of 17 healthy rabbits and 23 cancer‑bearing rabbits, of which 15 developed cancer in the lung (cancer group) and 8 developed lung cancer in the follow-up period (pre-cancer group). Data were obtained using a PBSII-C protein chip reader and analyzed using Biomarker Wizard and Proteinchip 3.1 software. Compared with the healthy rabbits, a total of 5 biomarkers were identified to be differentially expressed among 32 proteins screened from the sera in the cancer group and the pre-cancer group (P<0.05): 3 of the 5 biomarkers were upregulated and 2 were downregulated. Protein mass spectro-metry can be used to identify specific molecules closely correlated with the progression of lung cancer and, thus, this method may become an effective tool for the early diagnosis or prediction of lung cancer. |
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Authors:
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Xin Li; Weixing Liu; Baowei Dong; Lin Sheng; He Ren; Zhiyu Han; Tong Lu; Ping Liang |
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Publication Detail:
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Type: Journal Article Date: 2012-06-18 |
Journal Detail:
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Title: Molecular medicine reports Volume: 6 ISSN: 1791-3004 ISO Abbreviation: Mol Med Rep Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-07-06 Completed Date: 2012-11-06 Revised Date: 2013-02-22 |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 531-4 Citation Subset: IM |
Affiliation:
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Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing 100853, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / blood* Lung Neoplasms / metabolism*, pathology Protein Array Analysis Rabbits Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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