Document Detail


Identification of serum biomarkers for lung cancer using protein mass spectrometry.
MedLine Citation:
PMID:  22710637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prior to pathological changes becoming apparent in any disease, the component and amount of intracellular proteins may undergo alteration. Thus, monitoring of proteins may be used to screen indicators in order to identify prognostic markers. The aim of this study was to investigate the feasibility of identification of serum biomarkers for lung cancer using protein mass spectrometry. Surface-enhanced laser desorption/ionization (SELDI) and weak cation exchange 2 (WCX2) protein chip array were employed for protein profiling of the sera of 17 healthy rabbits and 23 cancer‑bearing rabbits, of which 15 developed cancer in the lung (cancer group) and 8 developed lung cancer in the follow-up period (pre-cancer group). Data were obtained using a PBSII-C protein chip reader and analyzed using Biomarker Wizard and Proteinchip 3.1 software. Compared with the healthy rabbits, a total of 5 biomarkers were identified to be differentially expressed among 32 proteins screened from the sera in the cancer group and the pre-cancer group (P<0.05): 3 of the 5 biomarkers were upregulated and 2 were downregulated. Protein mass spectro-metry can be used to identify specific molecules closely correlated with the progression of lung cancer and, thus, this method may become an effective tool for the early diagnosis or prediction of lung cancer.
Authors:
Xin Li; Weixing Liu; Baowei Dong; Lin Sheng; He Ren; Zhiyu Han; Tong Lu; Ping Liang
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Publication Detail:
Type:  Journal Article     Date:  2012-06-18
Journal Detail:
Title:  Molecular medicine reports     Volume:  6     ISSN:  1791-3004     ISO Abbreviation:  Mol Med Rep     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-06     Completed Date:  2012-11-06     Revised Date:  2013-02-22    
Medline Journal Info:
Nlm Unique ID:  101475259     Medline TA:  Mol Med Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  531-4     Citation Subset:  IM    
Affiliation:
Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing 100853, PR China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / blood*
Lung Neoplasms / metabolism*,  pathology
Protein Array Analysis
Rabbits
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Biological Markers

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