Document Detail


Identification of serum amyloid A in the serum of gastric cancer patients by protein expression profiling.
MedLine Citation:
PMID:  22783429     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purpose of this study was to screen serum samples from gastric carcinoma patients and to determine whether serum amyloid A protein (SAA) served as a biomarker. SELDI technology was used to screen for changes in SAA levels in the serum samples. A mass cluster with a mass/charge (m/z) value between 11.1 and 11.9 kDa was identified in the serum samples from gastric carcinoma patients which was much higher than that of the control group. Furthermore, the increase in this m/z peak correlated with the severity of the cancer. High-performance liquid chromatography (HPLC) analysis confirmed that the peak was SAA1. In conclusion, this increase in SAA may be used as a potential biomarker for gastric cancer.
Authors:
Chibo Liu; Chunqin Pan; Jianmin Shen; Haibao Wang; Liang Yong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-30
Journal Detail:
Title:  Oncology letters     Volume:  3     ISSN:  1792-1082     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531236     Medline TA:  Oncol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1259-1262     Citation Subset:  -    
Affiliation:
Department of Clinical Laboratory, Taizhou Municipal Hospital, Taizhou, Zhejiang 318000, P.R. China.
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