| Identification of ricinoleic acid as an inhibitor of Ca2+ signal-mediated cell-cycle regulation in budding yeast. | |
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MedLine Citation:
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PMID: 19958388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Free fatty acids exhibit diverse biological effects such as the regulation of immune responses in humans and animals. To investigate the biological effect of fatty acids in the model eukaryotic organism yeast, we examined the activity of various fatty acids in a yeast-based drug-screening system designed to detect the small-molecule compounds that inhibit Ca(2+)-signal-mediated cell-cycle regulation. Among the fatty acids examined, ricinoleic acid markedly alleviated the deleterious physiological effects induced by the compelled activation of Ca(2+) signaling by external CaCl(2), such as the polarized bud growth and the growth arrest in the G(2) phase. In accordance with the physiological consequences induced by ricinoleic acid, it diminished the Ca(2+)-induced phosphorylation of Cdc28p at Tyr-19, concomitant with the decrease in the Ca(2+)-stimulated expression levels of Cln2p and Swe1p. |
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Authors:
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Siriluck Attrapadung; Jun Yoshida; Ken-ichi Kimura; Masaki Mizunuma; Tokichi Miyakawa; Benjamas Wongsatayanon Thanomsub |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-01 |
Journal Detail:
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Title: FEMS yeast research Volume: 10 ISSN: 1567-1364 ISO Abbreviation: FEMS Yeast Res. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-03-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101085384 Medline TA: FEMS Yeast Res Country: England |
Other Details:
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Languages: eng Pagination: 38-43 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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CDC2-CDC28 Kinases
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metabolism Calcium Chloride / metabolism Calcium Signaling / drug effects* Cell Cycle / drug effects* Cell Cycle Proteins / biosynthesis Cyclins / biosynthesis Growth Inhibitors / pharmacology* Phosphorylation Protein-Tyrosine Kinases / biosynthesis Ricinoleic Acids / pharmacology* Saccharomyces cerevisiae / drug effects* Saccharomyces cerevisiae Proteins / biosynthesis, metabolism |
| Chemical | |
Reg. No./Substance:
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0/CLN2 protein, S cerevisiae; 0/Cell Cycle Proteins; 0/Cyclins; 0/Growth Inhibitors; 0/Ricinoleic Acids; 0/Saccharomyces cerevisiae Proteins; 10043-52-4/Calcium Chloride; 141-22-0/ricinoleic acid; EC 2.7.1.-/SWE1 protein, S cerevisiae; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.11.22/CDC2-CDC28 Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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