Document Detail


Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva.
MedLine Citation:
PMID:  6318707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arachidonic-acid metabolites were identified in salivary secretions of rabbits, rats and man and in homogenates of rabbit parotid and submandibular glands. The following levels were determined in mixed saliva of healthy volunteers: PGE2, 0.65 +/- 0.8 ng/ml; PGF2 alpha, 0.41 +/- 0.06 ng/ml; serologically active hydroxyeicosatetraenoic acids (HETE) 319.6 +/- 36.6 ng/ml; serologically active 6-sulphidopeptide-containing leukotrienes 1.72 +/- 0.21 ng/ml (all values mean +/- SEM). In all instances, HETE markedly predominated over all other arachidonic-acid metabolites.
Authors:
B Rigas; R A Lewis; K F Austen; E J Corey; L Levine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of oral biology     Volume:  28     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1031-5     Citation Subset:  D; IM    
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MeSH Terms
Descriptor/Qualifier:
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Animals
Arachidonic Acid
Arachidonic Acids / analysis,  metabolism*
Chromatography, High Pressure Liquid
Dinoprost
Dinoprostone
Endocrine Glands / analysis
Exocrine Glands / analysis
Female
Humans
Leukotriene B4 / analysis
Male
Prostaglandins E / analysis
Prostaglandins F / analysis
Rabbits
Radioimmunoassay
Rats
Rats, Inbred Strains
Saliva / analysis*
Grant Support
ID/Acronym/Agency:
AI-10356/AI/NIAID NIH HHS; CA-17309/CA/NCI NIH HHS; GM-27256/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins E; 0/Prostaglandins F; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; 551-11-1/Dinoprost; 59985-28-3/12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 71160-24-2/Leukotriene B4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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