Document Detail


Identification and quantification of octanoyl glucuronide in the urine of children who ingested medium-chain triglycerides.
MedLine Citation:
PMID:  2948585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to the previously described metabolites, octanoyl glucuronide was identified in the urine of four children who received medium-chain triglycerides. Octanoyl glucuronide in the urine of a child after ingestion of medium-chain triglycerides (C8:C10, 3:1) was quantitated as octanoic acid after glucuronidase treatment by means of gas chromatography/mass spectrometry. The urinary excretion increased rapidly to a maximum 1-2 h after ingestion, and decreased thereafter. During 0-3 h, 6.11 mumol of octanoyl glucuronide was excreted, which comprised 0.034% octanoic acid administered as glyceride, and 0.07% octanoic acid was postulated to be excreted as glucuronide within 24 h. Neither decanoyl glucuronide nor hexanoyl glucuronide was detected. Glucuronidation of branched medium-chain fatty acids, whose beta-oxidation is hindered, has been described previously. The present findings show that even straight-chain fatty acids undergo glucuronidation, although to a lesser extent, in addition to omega-oxidation and beta-oxidation.
Authors:
T Kuhara; I Matsumoto; M Ohno; T Ohura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomedical & environmental mass spectrometry     Volume:  13     ISSN:  0887-6134     ISO Abbreviation:  Biomed. Environ. Mass Spectrom.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-03-04     Completed Date:  1987-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8603224     Medline TA:  Biomed Environ Mass Spectrom     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  595-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Caprylates / urine*
Child
Chromatography, Gas
Glucuronates / urine
Humans
Molecular Weight
Octanoic Acids / urine*
Triglycerides / administration & dosage,  metabolism*
Chemical
Reg. No./Substance:
0/Caprylates; 0/Glucuronates; 0/Octanoic Acids; 0/Triglycerides; 99910-55-1/octanoylglucuronide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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