Document Detail


Identification and properties of a novel variant of Na+/HCO3- cotransporter 4 (NBC4) predominantly expressed in choroid plexus.
MedLine Citation:
PMID:  23205667     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Secretion of HCO3- at the apical side of the epithelial cells of the choroid plexus is an essential step in the formation of cerebrospinal fluid. Anion conductance with a high degree of HCO3- permeability has been observed and suggested to be the major pathway for HCO3- transport across the apical membrane. Recently, it was found that Na+/HCO3- cotransporter 4 (NBC4), an electrogenic member of the NBC family, was expressed in the choroid plexus. We found that a novel variant of the NBC4 (NBC4g/Slc4a5-g) is almost exclusively expressed in the apical membrane of rat choroid plexus epithelium at exceptionally high levels. RNA interference-mediated knockdown allowed the functional demonstration that NBC4g is the major player in the HCO3- transport across the apical membrane of the choroid plexus epithelium. If combined with a recent observation that in choroid plexus epithelial cells electrogenic NBC operates with a stoichiometry of 3:1, these results suggest that NBC4g mediates efflux of HCO3- and contributes to cerebrospinal fluid production.
Authors:
Hidekazu Fukuda; Taku Hirata; Nobuhiro Nakamura; Akira Kato; Katsumasa Kawahara; Shigeo Wakabayashi; Min-Hwang Chang; Michael F Romero; Shigehisa Hirose
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  The Biochemical journal     Volume:  -     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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