| Identification and properties of a novel variant of Na+/HCO3- cotransporter 4 (NBC4) predominantly expressed in choroid plexus. | |
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MedLine Citation:
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PMID: 23205667 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Secretion of HCO3- at the apical side of the epithelial cells of the choroid plexus is an essential step in the formation of cerebrospinal fluid. Anion conductance with a high degree of HCO3- permeability has been observed and suggested to be the major pathway for HCO3- transport across the apical membrane. Recently, it was found that Na+/HCO3- cotransporter 4 (NBC4), an electrogenic member of the NBC family, was expressed in the choroid plexus. We found that a novel variant of the NBC4 (NBC4g/Slc4a5-g) is almost exclusively expressed in the apical membrane of rat choroid plexus epithelium at exceptionally high levels. RNA interference-mediated knockdown allowed the functional demonstration that NBC4g is the major player in the HCO3- transport across the apical membrane of the choroid plexus epithelium. If combined with a recent observation that in choroid plexus epithelial cells electrogenic NBC operates with a stoichiometry of 3:1, these results suggest that NBC4g mediates efflux of HCO3- and contributes to cerebrospinal fluid production. |
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Authors:
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Hidekazu Fukuda; Taku Hirata; Nobuhiro Nakamura; Akira Kato; Katsumasa Kawahara; Shigeo Wakabayashi; Min-Hwang Chang; Michael F Romero; Shigehisa Hirose |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-4 |
Journal Detail:
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Title: The Biochemical journal Volume: - ISSN: 1470-8728 ISO Abbreviation: Biochem. J. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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