Document Detail

Identification and potential role of PSD-95 in Schwann cells.
MedLine Citation:
PMID:  18941934     Owner:  NLM     Status:  MEDLINE    
Postsynaptic density-95 (PSD-95) is one of neuronal nitric oxide synthase (nNOS)-anchoring proteins and plays an important role in specifying the sites of reaction of nitric oxide (NO) in the nervous system. The present study aims to investigate the presence of PSD-95 in rat Schwann cells (SCs) and the association of PSD-95 and nNOS with serum-induced SCs proliferation. The expression of both molecules downregulated significantly after 48 h of serum deprivation, and increased gradually to the peak at 12 h, ultimately returned to the control level at 48 h after serum stimulation. The association of PSD-95 with nNOS was observed in Ki67 and BrdU-positive SCs. The selective nNOS inhibitor arrested the cell cycle progress and decreased the proliferating cell nuclear antigen (PCNA) levels. These findings suggested that PSD-95 and nNOS may collectively participate in the proliferation of SCs, providing further evidence for the role of NO during peripheral nerve regeneration.
Aiguo Shen; Shangfeng Gao; Zhiyun Ben; Haibo Wang; Junxia Jia; Tao Tao; Shugiong Niu; Xin Li; Chun Cheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-21
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  29     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  321-30     Citation Subset:  IM    
The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, China.
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MeSH Terms
Bromodeoxyuridine / metabolism
Cell Cycle / drug effects
Cell Proliferation / drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Down-Regulation / drug effects,  physiology
Enzyme Inhibitors / pharmacology
Flow Cytometry
Indazoles / pharmacology
Intracellular Signaling Peptides and Proteins / genetics,  metabolism*
Ki-67 Antigen / metabolism
Membrane Proteins / genetics,  metabolism*
Nitric Oxide Synthase Type I / genetics,  metabolism
Proliferating Cell Nuclear Antigen / metabolism
Rats, Sprague-Dawley
S100 Proteins / metabolism
Schwann Cells / drug effects,  metabolism*
Sciatic Nerve / cytology
Serum / physiology
Time Factors
Reg. No./Substance:
0/Dlgh4 protein, rat; 0/Enzyme Inhibitors; 0/Indazoles; 0/Intracellular Signaling Peptides and Proteins; 0/Ki-67 Antigen; 0/Membrane Proteins; 0/Proliferating Cell Nuclear Antigen; 0/S100 Proteins; 2942-42-9/7-nitroindazole; 59-14-3/Bromodeoxyuridine; EC Oxide Synthase Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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