Document Detail


Identification and potential role of PSD-95 in Schwann cells.
MedLine Citation:
PMID:  18941934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postsynaptic density-95 (PSD-95) is one of neuronal nitric oxide synthase (nNOS)-anchoring proteins and plays an important role in specifying the sites of reaction of nitric oxide (NO) in the nervous system. The present study aims to investigate the presence of PSD-95 in rat Schwann cells (SCs) and the association of PSD-95 and nNOS with serum-induced SCs proliferation. The expression of both molecules downregulated significantly after 48 h of serum deprivation, and increased gradually to the peak at 12 h, ultimately returned to the control level at 48 h after serum stimulation. The association of PSD-95 with nNOS was observed in Ki67 and BrdU-positive SCs. The selective nNOS inhibitor arrested the cell cycle progress and decreased the proliferating cell nuclear antigen (PCNA) levels. These findings suggested that PSD-95 and nNOS may collectively participate in the proliferation of SCs, providing further evidence for the role of NO during peripheral nerve regeneration.
Authors:
Aiguo Shen; Shangfeng Gao; Zhiyun Ben; Haibo Wang; Junxia Jia; Tao Tao; Shugiong Niu; Xin Li; Chun Cheng
Related Documents :
8261134 - Negative regulation of schwann cell myelin protein gene expression by the dorsal root g...
10098854 - Developmental neurotoxicity of phenytoin on granule cells and purkinje cells in mouse c...
3272164 - Neuronal influence on glial enzyme expression: evidence from chimeric mouse cerebellum.
21573494 - Interstitial cells of cajal (icc)-like-c-kit positive cells are involved in gastritis a...
7548224 - Phosphorylation of eukaryotic elongation factor 2 in differentiating and proliferating ...
10685544 - Phase-dependent influence of nonsteroidogenic cells on steroidogenesis and prostaglandi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-21
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  29     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  321-30     Citation Subset:  IM    
Affiliation:
The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bromodeoxyuridine / metabolism
Cell Cycle / drug effects
Cell Proliferation / drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Down-Regulation / drug effects,  physiology
Enzyme Inhibitors / pharmacology
Flow Cytometry
Indazoles / pharmacology
Intracellular Signaling Peptides and Proteins / genetics,  metabolism*
Ki-67 Antigen / metabolism
Membrane Proteins / genetics,  metabolism*
Nitric Oxide Synthase Type I / genetics,  metabolism
Proliferating Cell Nuclear Antigen / metabolism
Rats
Rats, Sprague-Dawley
S100 Proteins / metabolism
Schwann Cells / drug effects,  metabolism*
Sciatic Nerve / cytology
Serum / physiology
Time Factors
Chemical
Reg. No./Substance:
0/Dlgh4 protein, rat; 0/Enzyme Inhibitors; 0/Indazoles; 0/Intracellular Signaling Peptides and Proteins; 0/Ki-67 Antigen; 0/Membrane Proteins; 0/Proliferating Cell Nuclear Antigen; 0/S100 Proteins; 2942-42-9/7-nitroindazole; 59-14-3/Bromodeoxyuridine; EC 1.14.13.39/Nitric Oxide Synthase Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rehabilitation of sensorimotor integration deficits in balance impairment of patients with stroke he...
Next Document:  Symptomatic cluster-like headache triggered by forehead lipoma: a case report and review of the lite...