| Identification of possible biomarkers for breast cancer from free fatty acid profiles determined by GC-MS and multivariate statistical analysis. | |
| | |
MedLine Citation:
|
PMID: 22061338 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: The aim was to investigate the free fatty acid (FFA) metabolic profiles and to identify biomarkers that can be used to distinguish patients with breast cancer (BC) from benign (BE) patients or healthy controls. DESIGN AND METHODS: A total of 114 subjects were divided into the following three groups: BC patients, BE patients and controls. The FFA profiles in three groups were studied by gas chromatography-mass spectrometry coupled with multivariate statistical analysis. RESULTS: Three saturated fatty acids (C14:0, C16:0 and C18:0) and three unsaturated fatty acids (C18:2, C18:3 and C20:5) in BC were significantly different than controls. Palmitic acid, stearic acid, linoleic acid and total FFA were identified as potential biomarkers distinguished BC from the other groups. CONCLUSION: The alterations of FFA could reflect underlying metabolic changes in BC patients, and this study has demonstrated that FFA biomarkers might be helpful for prevention and characterization of BC patients. |
| | |
Authors:
|
Wuwen Lv; Tongshu Yang |
Related Documents
:
|
21835288 - A multicenter comparison of established and emerging cardiac biomarkers for the diagnos... 22071008 - Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid co... 22639218 - Metabolic pathway determination and flux analysis in nonmodel microorganisms through (1... 11425728 - Role of fatty acid de novo biosynthesis in polyhydroxyalkanoic acid (pha) and rhamnolip... 19012528 - The effect of the mode of delivery on maternal-neonatal interleukin-6, biogenic amine a... 9630958 - Expression of a cyanobacterial delta 6-desaturase gene results in gamma-linolenic acid ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-26 |
Journal Detail:
|
Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
|
Harbin University of Commence, Harbin, 150028, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Correlation of creatinine with TSH levels in overt hypothyroidism - A requirement for monitoring of ...
Next Document: Substance use in lesbian, gay, and bisexual populations: An update on empirical research and implica...