| Identification of photoproducts of folic acid and its degradation pathways in aqueous solution. | |
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MedLine Citation:
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PMID: 12615247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The UV irradiated aqueous solutions of folic acid at pH 2-10 degrade to give pterin-6-carboxylic acid and p-aminobenzoyl-L-glutamic acid under aerobic conditions. These photoproducts have been identified by TLC, HPLC and Spectrophotometric techniques. A reaction scheme for the photodegradation pathways of folic acid leading to the formation of the photoproducts in acid and alkaline media has been proposed which involves the participation of an enamine intermediate. |
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Authors:
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M Jamil Akhtar; M Ataullah Khan; Iqbal Ahmad |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 31 ISSN: 0731-7085 ISO Abbreviation: J Pharm Biomed Anal Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-04 Completed Date: 2003-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: England |
Other Details:
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Languages: eng Pagination: 579-88 Citation Subset: IM |
Affiliation:
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Research and Development Laboratories, GlaxoSmithKline Pakistan Ltd., F-268, S.I.T.E, Karachi, Pakistan. jxa4510@glaxowellcome.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid Chromatography, Thin Layer Folic Acid / chemistry* Hydrogen-Ion Concentration Photochemistry Solutions Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
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0/Solutions; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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