Document Detail


Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic.
MedLine Citation:
PMID:  21390147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.
METHODS: A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer. Clinical data and pathology features of the tumor were obtained from chart review.
RESULTS: Of the 212 CRC patients recruited, 61 (29%) reported a family history of CRC, 45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC. Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients, respectively. Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype, which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001). Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment.
CONCLUSION: A significant proportion of patients with CRC were at high risk for LS. Education and training of health care professionals are essential to ensure proper management.
Authors:
Patrícia Koehler-Santos; Patricia Izetti; Jamile Abud; Carlos Eduardo Pitroski; Silvia Liliana Cossio; Suzi Alves Camey; Cláudio Tarta; Daniel C Damin; Paulo Carvalho Contu; Mario Antonello Rosito; Patricia Ashton-Prolla; João Carlos Prolla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-10     Completed Date:  2011-07-18     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  766-73     Citation Subset:  IM    
Affiliation:
Genomic Medicine Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, 90035-903, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Brazil
Colorectal Neoplasms / genetics*,  pathology,  surgery*
Colorectal Neoplasms, Hereditary Nonpolyposis / genetics*,  physiopathology
Colorectal Surgery
Female
Genetic Predisposition to Disease*
Humans
Male
Microsatellite Instability
Middle Aged
Risk Factors
Young Adult
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