| Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic. | |
| | |
MedLine Citation:
|
PMID: 21390147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil. METHODS: A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer. Clinical data and pathology features of the tumor were obtained from chart review. RESULTS: Of the 212 CRC patients recruited, 61 (29%) reported a family history of CRC, 45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC. Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients, respectively. Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype, which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001). Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment. CONCLUSION: A significant proportion of patients with CRC were at high risk for LS. Education and training of health care professionals are essential to ensure proper management. |
| | |
Authors:
|
Patrícia Koehler-Santos; Patricia Izetti; Jamile Abud; Carlos Eduardo Pitroski; Silvia Liliana Cossio; Suzi Alves Camey; Cláudio Tarta; Daniel C Damin; Paulo Carvalho Contu; Mario Antonello Rosito; Patricia Ashton-Prolla; João Carlos Prolla |
Related Documents
:
|
21346967 - Predicting patient's trajectory of physiological data using temporal trends in similar ... 21177327 - Familial multiple sclerosis: does consanguinity have a role? 23143857 - Workload and usefulness of daily, centralized home monitoring for patients treated with... 21305487 - Postural orthostatic tachycardia syndrome following lyme disease. 20919597 - Treating patients with delusions of parasitosis: a blueprint for clinicians. 8073807 - Methotrexate in psoriatic polyarthritis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-03-10 Completed Date: 2011-07-18 Revised Date: 2011-07-26 |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 766-73 Citation Subset: IM |
Affiliation:
|
Genomic Medicine Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, 90035-903, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Brazil Colorectal Neoplasms / genetics*, pathology, surgery* Colorectal Neoplasms, Hereditary Nonpolyposis / genetics*, physiopathology Colorectal Surgery Female Genetic Predisposition to Disease* Humans Male Microsatellite Instability Middle Aged Risk Factors Young Adult |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer.
Next Document: Single center experience of capsule endoscopy in patients with obscure gastrointestinal bleeding.