| Identification of okadaic acid production in the marine dinoflagellate Prorocentrum rhathymum from Florida Bay. | |
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MedLine Citation:
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PMID: 19735671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracts of fifty-seven newly isolated strains of dinoflagellates and raphidophytes were screened for protein phosphatase (PP2A) inhibition. Five strains, identified by rDNA sequence analysis as Prorocentrum rhathymum, tested positive and the presence of okadaic acid was confirmed in one strain by HPLC-MS/MS and by HPLC with fluorescence detection and HPLC-MS of the okadaic acid ADAM derivative. Quantitation of the ADAM derivative indicated that the concentration of okadaic acid in the culture medium is 0.153 microg/L. |
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Authors:
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Tianying An; Jamie Winshell; Gloria Scorzetti; Jack W Fell; Kathleen S Rein |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-09-06 |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 55 ISSN: 1879-3150 ISO Abbreviation: Toxicon Publication Date: 2010 Feb-Mar |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-08 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: England |
Other Details:
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Languages: eng Pagination: 653-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th St., Miami, FL 33199, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Chromatography, High Pressure Liquid DNA / analysis, genetics Databases, Genetic Dinoflagellida / genetics, metabolism* Florida Mass Spectrometry Molecular Sequence Data Okadaic Acid / metabolism*, pharmacology Protein Phosphatase 2 / antagonists & inhibitors Spectrometry, Fluorescence |
| Grant Support | |
ID/Acronym/Agency:
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P50 ES012736-019003/ES/NIEHS NIH HHS; P50 ES012736-029003/ES/NIEHS NIH HHS; P50 ES012736-039003/ES/NIEHS NIH HHS; P50 ES012736-049003/ES/NIEHS NIH HHS; P50 ES012736-059003/ES/NIEHS NIH HHS; P50 ES12736-01/ES/NIEHS NIH HHS; S11 ES011181-05/ES/NIEHS NIH HHS; S11 ES011181-059001/ES/NIEHS NIH HHS; S11 ES011181-069003/ES/NIEHS NIH HHS; S11 ES011181-07/ES/NIEHS NIH HHS; S11 ES011181-079002/ES/NIEHS NIH HHS; S11 ES011181-079003/ES/NIEHS NIH HHS; S11 ES011181-08/ES/NIEHS NIH HHS; S11 ES011181-089002/ES/NIEHS NIH HHS; S11 ES011181-089003/ES/NIEHS NIH HHS; S11 ES11181/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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78111-17-8/Okadaic Acid; 9007-49-2/DNA; EC 3.1.3.16/Protein Phosphatase 2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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