Document Detail

Identification of okadaic acid production in the marine dinoflagellate Prorocentrum rhathymum from Florida Bay.
MedLine Citation:
PMID:  19735671     Owner:  NLM     Status:  MEDLINE    
Extracts of fifty-seven newly isolated strains of dinoflagellates and raphidophytes were screened for protein phosphatase (PP2A) inhibition. Five strains, identified by rDNA sequence analysis as Prorocentrum rhathymum, tested positive and the presence of okadaic acid was confirmed in one strain by HPLC-MS/MS and by HPLC with fluorescence detection and HPLC-MS of the okadaic acid ADAM derivative. Quantitation of the ADAM derivative indicated that the concentration of okadaic acid in the culture medium is 0.153 microg/L.
Tianying An; Jamie Winshell; Gloria Scorzetti; Jack W Fell; Kathleen S Rein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-09-06
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  55     ISSN:  1879-3150     ISO Abbreviation:  Toxicon     Publication Date:    2010 Feb-Mar
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-08     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  653-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
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MeSH Terms
Amino Acid Sequence
Chromatography, High Pressure Liquid
DNA / analysis,  genetics
Databases, Genetic
Dinoflagellida / genetics,  metabolism*
Mass Spectrometry
Molecular Sequence Data
Okadaic Acid / metabolism*,  pharmacology
Protein Phosphatase 2 / antagonists & inhibitors
Spectrometry, Fluorescence
Grant Support
P50 ES012736/ES/NIEHS NIH HHS; P50 ES012736-019003/ES/NIEHS NIH HHS; P50 ES012736-029003/ES/NIEHS NIH HHS; P50 ES012736-039003/ES/NIEHS NIH HHS; P50 ES012736-049003/ES/NIEHS NIH HHS; P50 ES012736-059003/ES/NIEHS NIH HHS; P50 ES12736-01/ES/NIEHS NIH HHS; S11 ES011181/ES/NIEHS NIH HHS; S11 ES011181-05/ES/NIEHS NIH HHS; S11 ES011181-059001/ES/NIEHS NIH HHS; S11 ES011181-069003/ES/NIEHS NIH HHS; S11 ES011181-07/ES/NIEHS NIH HHS; S11 ES011181-079002/ES/NIEHS NIH HHS; S11 ES011181-079003/ES/NIEHS NIH HHS; S11 ES011181-08/ES/NIEHS NIH HHS; S11 ES011181-089002/ES/NIEHS NIH HHS; S11 ES011181-089003/ES/NIEHS NIH HHS; S11 ES11181/ES/NIEHS NIH HHS
Reg. No./Substance:
1W21G5Q4N2/Okadaic Acid; 9007-49-2/DNA; EC Phosphatase 2

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