Document Detail


Identification of novel plasmin inhibitors possessing nitrile moiety as warhead.
MedLine Citation:
PMID:  21944858     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Lysine-nitrile derivatives having a trisubstituted benzene, which belongs to a new chemical class, were prepared and tested for inhibitory activities against plasmin and the highly homologous plasma kallikrein and urokinase. The use of the novel chemotype in the development of plasmin inhibitors has been demonstrated by derivatives of compound 9.
Authors:
Naoki Teno; Keigo Gohda; Keiko Wanaka; Takuya Sueda; Yuko Tsuda
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Publication Detail:
Type:  -     Date:  2011-9-1
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Hiroshima International University, Faculty of Pharmaceutical Science, 5-1-1, Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
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