| Identification of novel plasmin inhibitors possessing nitrile moiety as warhead. | |
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MedLine Citation:
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PMID: 21944858 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lysine-nitrile derivatives having a trisubstituted benzene, which belongs to a new chemical class, were prepared and tested for inhibitory activities against plasmin and the highly homologous plasma kallikrein and urokinase. The use of the novel chemotype in the development of plasmin inhibitors has been demonstrated by derivatives of compound 9. |
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Authors:
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Naoki Teno; Keigo Gohda; Keiko Wanaka; Takuya Sueda; Yuko Tsuda |
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Publication Detail:
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Type: - Date: 2011-9-1 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: - ISSN: 1464-3405 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Hiroshima International University, Faculty of Pharmaceutical Science, 5-1-1, Hirokoshingai, Kure, Hiroshima 737-0112, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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