Document Detail

Identification of novel microRNAs negatively regulating cardiac hypertrophy.
MedLine Citation:
PMID:  23068096     Owner:  NLM     Status:  Publisher    
MicroRNAs (miRNAs) are endogenous small noncoding RNA molecules that suppress gene expression via degradation or translational inhibition of their target genes. Many miRNAs are associated with cardiac hypertrophy and heart failure. In this study, we pursued to identify miRNAs that negatively regulate cardiac hypertrophy by utilizing a surgical model for regression of cardiac hypertrophy. Microarray analysis revealed that 15 miRNAs out of the 696 miRNAs tested were specifically up-regulated during the regression period. Among these regression-specific miRNAs, nine microRNAs, which have not been previously reported, were further tested for their effects on phenylephrine (PE)-treated neonatal cardiomyocytes. Consequently, five miRNAs (miR-101b, 142-3p, 181d, 24-2∗, and 450a) completely abrogated PE-induced hypertrophy as determined by measurements of cell size and fetal gene expression. Conversely, antagomers of these miRNAs exacerbated the PE-induced hypertrophy. Collectively, these findings suggest that the five miRNAs newly identified by using our cardiac hypertrophy-regression surgical model negatively regulate cardiac hypertrophy and could be used as potential therapeutic targets for the treatment of heart diseases.
Moon Hee Jeong; Jong Sub Lee; Do Han Kim; Woo Jin Park; Dong Kwon Yang
Related Documents :
2536096 - The epstein-barr virus (ebv) early promoter dr contains a cis-acting element responsive...
8774886 - Transcription activation in cells lacking tafiis.
10721736 - Molecular cloning and functional characterization of the mouse mafb gene.
21969146 - Functions of noncoding rnas in neural development and neurological diseases.
15654066 - Long-term constant light induces constitutive elevated expression of mper2 protein in t...
8200476 - Alterations in protein synthesis following transplantation of mouse 8-cell stage nuclei...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  -     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
College of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of ?-catenin.
Next Document:  Regulation of adipolin/CTRP12 cleavage by obesity.