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Identification of novel interleukin 1 beta family genes in Japanese Flounder Paralichthys olivaceus.
MedLine Citation:
PMID:  23069785     Owner:  NLM     Status:  Publisher    
Gene in the interleukin 1 family plays a central role in the regulation of immune and inflammatory responses. Here, we describe two novel IL-1-like gene in Japanese flounder Paralichthys olivaceus (jfIL1-L1 and jfIL1-L2). jfIL1â-L1 was homologous to Nile Tilapia IL-1â-like gene and Arctic char IL-1, and jfIL1â-L2 showed homology to hypothetical protein LOC100699119 of Nile Tilapia and rainbow trout Oncorhynchus mykiss IL-1 receptor agonist (RA). The deduced amino acids sequences of these IL-1â-like genes showed very low identities to the Japanese flounder IL-1 (jfIL-1). Phylogenetic analysis confirmed that jfIL1â-L1 and -L2 were distinct from jfIL-1. The gene encoding the predicted ORF of jfIL1â-L1 and -L2 is divided into 6 exons and 7 exons, respectively. Transcripts of jfIL1â-L1 were detected in gills, intestine, kidney and spleen, and those of jfIL1â-L2 were detected in gills, intestine and spleen. The mRNA levels of jfIL1â-L1 and -L2 were not effect or slightly decreased by treatment with LPS and the formalin-killed cells of Edwardsiella tarda whilst mRNA levels of jfIL1â were significantly increased in the kidney and spleen at 6 hours by these treatments.
Apichaya Taechavasonyoo; Hidehiro Kondo; Reiko Nozaki; Yutaka Suzuki; Ikuo Hirono
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Fish & shellfish immunology     Volume:  -     ISSN:  1095-9947     ISO Abbreviation:  Fish Shellfish Immunol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505220     Medline TA:  Fish Shellfish Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato, Tokyo 108-8477, Japan.
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