Document Detail

Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.
MedLine Citation:
PMID:  16962325     Owner:  NLM     Status:  MEDLINE    
Novel inhibitors of Trypanosoma brucei and mammalian UDP-Glc 4'-epimerase were identified by screening a small library of natural products and commercially available drug-like molecules. The inhibitors possess low micromolar potency against the T. brucei and human enzymes in vitro, display a degree of selectivity between the two enzymes, and are cytotoxic to cultured T. brucei and mammalian cells.
Michael D Urbaniak; Jioji N Tabudravu; Aichi Msaki; Kathy Mansfield Matera; Ruth Brenk; Marcel Jaspars; Michael A J Ferguson
Related Documents :
11564055 - Therapeutic drug monitoring of cytotoxic drugs.
21375615 - Buying cannabis in 'coffee shops'.
25314005 - Silicone surface with drug nano-depots for medical devices.
16061845 - Maintenance therapy to suppress micrometastasis: the new challenge for adjuvant cancer ...
16580355 - Induction of ovulation and ovarian cancer: a critical review of the literature.
3321135 - Medical and psychiatric implications of generic drugs.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2006-09-07
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  16     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-09     Completed Date:  2007-01-03     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  5744-7     Citation Subset:  IM    
Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Enzyme Inhibitors / chemistry,  pharmacology*
Models, Chemical
Trypanocidal Agents / chemistry,  pharmacology*,  therapeutic use
Trypanosoma brucei brucei / drug effects*,  growth & development
Trypanosomiasis, African / drug therapy*
UDPglucose 4-Epimerase / antagonists & inhibitors*
Grant Support
071463//Wellcome Trust
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Trypanocidal Agents; EC 4-Epimerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characterization of manures from fish cage farming in Chile.
Next Document:  Rapid microwave-assisted fluorination yielding novel 5'-deoxy-5'-fluorouridine derivatives.