Document Detail

Identification of a novel herpesvirus from a California desert tortoise (Gopherus agassizii).
MedLine Citation:
PMID:  16253444     Owner:  NLM     Status:  MEDLINE    
Herpesviruses are significant pathogens of tortoises, causing upper respiratory tract disease and necrotizing stomatitis, with infections often associated with high mortality rates. Herpesvirus infection in a captive California desert tortoise (Gopherus agassizii) was detected by light microscopic observation of intranuclear inclusion bodies in various tissues followed by transmission electron microscopic observation of herpesvirus-like particles, and amplification of herpesvirus nucleic acid sequences using polymerase chain reaction. Using an indirect enzyme linked immunosorbent assay, anti-tortoise herpesvirus antibodies were detected one month after initial onset of clinical signs. This novel herpesvirus is distinct from the previously described tortoise herpesvirus (tortoise herpesvirus-1, THV-1) sharing 83% sequence identity of 60 amino acids of a portion of the DNA polymerase gene and 79% sequence identity across 120 amino acids of a portion of the ribonucleotide reductase gene. Similar to THV-1, this novel herpesvirus, tortoise herpesvirus-2 (THV-2), also clusters with the alphaherpesviruses.
April J Johnson; Allan P Pessier; James F X Wellehan; Roseanne Brown; Elliott R Jacobson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-25
Journal Detail:
Title:  Veterinary microbiology     Volume:  111     ISSN:  0378-1135     ISO Abbreviation:  Vet. Microbiol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-08     Completed Date:  2006-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705469     Medline TA:  Vet Microbiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  107-16     Citation Subset:  IM    
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, P.O. Box 100126, Gainesville, FL 32610, USA.
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MeSH Terms
Amino Acid Sequence
DNA, Viral / analysis*
Fatal Outcome
Herpesviridae / classification,  isolation & purification*,  ultrastructure
Herpesviridae Infections / epidemiology,  pathology,  veterinary*
Molecular Sequence Data
Polymerase Chain Reaction / methods,  veterinary*
Sequence Alignment / veterinary
Tongue / pathology,  virology
Turtles / virology*
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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