Document Detail


Identification of novel genetic loci for intraocular pressure: a genomewide scan of the Beaver Dam Eye Study.
MedLine Citation:
PMID:  17210855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To identify genetic loci that control intraocular pressure (IOP).
METHODS: We performed a genomewide scan of IOP, using 486 pedigrees ascertained through a population-based cohort, the Beaver Dam Eye Study. Linkage analysis was performed using the modified Haseman-Elston regression models and variance components linkage analysis.
RESULTS: Seven regions of interest were identified on chromosomes 2, 5, 6, 7, 12, 15, and 19. The novel linkage region on chromosome 19p had an empirical multipoint P value of 6.1 x 10(-5). Two of the regions (2 and 19) were especially interesting since each has been identified as a potential linkage region for blood pressure.
CONCLUSIONS: The results of this genomewide scan provide evidence that a quantitative trait locus may influence elevated IOP and may colocalize with blood pressure loci. These loci may control systemic pressure reflected in the eye and vascular system.
CLINICAL RELEVANCE: Glaucoma is a leading cause of blindness in the world, and the identification of genes that contribute to this disease is essential. Elevated IOP is a principal risk factor for primary open-angle glaucoma and an intriguing quantitative trait that may strongly influence the development of disease.
Authors:
Priya Duggal; Alison P Klein; Kristine E Lee; Ronald Klein; Barbara E K Klein; Joan E Bailey-Wilson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  125     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-09     Completed Date:  2007-01-30     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Blood Pressure / genetics
Chromosome Mapping
Chromosomes, Human, Pair 19 / genetics*
Female
Genetic Linkage*
Genetic Markers
Glaucoma, Open-Angle / genetics
Humans
Intraocular Pressure / genetics*
Male
Middle Aged
Polymerase Chain Reaction
Quantitative Trait Loci*
Wisconsin / epidemiology
Grant Support
ID/Acronym/Agency:
P41 RR003655/RR/NCRR NIH HHS; P41 RR003655-16/RR/NCRR NIH HHS; R01 EY010605/EY/NEI NIH HHS; R01 EY010605-04/EY/NEI NIH HHS; R01 EY015286/EY/NEI NIH HHS; R01 EY015286/EY/NEI NIH HHS; R01 EY015286-02/EY/NEI NIH HHS; RR03665/RR/NCRR NIH HHS; U10 EY006594/EY/NEI NIH HHS; U10 EY006594-13/EY/NEI NIH HHS; U10 EY06594/EY/NEI NIH HHS; Z01 HG200327-03/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers
Comments/Corrections
Comment In:
JAMA. 2007 Jan 17;297(3):306-7   [PMID:  17230643 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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