Document Detail


Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3.
MedLine Citation:
PMID:  9790758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We isolated by the differential display technique a novel gene that was expressed abundantly in adipose and female-specific tissues. The cDNA contained an open reading frame of 2097 nucleotides encoding a 699-amino-acid peptide. The predicted protein showed homology to several known extracellular matrix (ECM) proteins such as proteoglycan, keratocan, and decorin. Moreover, the amino acid sequence contained several possible functional domains that would participate in protein-protein interactions, including an RGD sequence, a von Willebrand factor domain (VWFC), and a leucine-rich repeat. These findings suggest that this novel protein functions in cell-cell and/or cell-ECM recognition processes. Northern blot analysis revealed expression predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus among 20 human adult tissues examined. We assigned the gene to chromosome 9q22.3 by means of fluorescence in situ hybridization.
Authors:
J Nishiu; T Tanaka; Y Nakamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  52     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-07     Completed Date:  1998-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  378-81     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Academic Press.
Affiliation:
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AB011792
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry
Amino Acid Sequence
Chromosome Mapping
Chromosomes, Human, Pair 9 / genetics*
Cloning, Molecular
Extracellular Matrix Proteins / chemistry*,  genetics*
Female
Humans
In Situ Hybridization, Fluorescence
Molecular Sequence Data
RNA, Messenger / genetics
Sequence Analysis, DNA
von Willebrand Factor / genetics
Chemical
Reg. No./Substance:
0/ECM2 protein, human; 0/Extracellular Matrix Proteins; 0/RNA, Messenger; 0/von Willebrand Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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