Document Detail

Identification of novel 'expressed sequence tags' within the FHIT gene locus in human chromosome region 3p14.2.
MedLine Citation:
PMID:  9225975     Owner:  NLM     Status:  MEDLINE    
Losses of genetic material within human chromosome regions (HCR) 3p12-p14 and 3p21-p22 are observed in various neoplasias, suggesting tumor suppressor gene (TSG) loci within these regions. HCR 3p14 is particularly interesting as it contains the t(3;8) translocation breakpoint of a hereditary renal cell carcinoma, the FRA3B fragile site, and DNA markers deleted in several types of human cancer. We here report on the identification of five novel 'expressed sequence tags' (ESTs) within 3p14.2 which map proximal to exon 9 of the candidate TSG, FHIT. These ESTs may be valuable for elucidation of the supposed TSG content in 3p14.2.
A Lux; W Bardenheuer; D Michael; F Bröcker; K Jülicher; L Vieten; S Michaelis; S Seeber; B Opalka; J Schütte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  100     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  90-5     Citation Subset:  IM    
Innere Klinik und Poliklinik (Tumorforschung), Universitätsklinikum Essen, Westdeutsches Tumorzentrum, Germany.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/W23309;  W23311;  W23312;  W23315;  W23316
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MeSH Terms
Acid Anhydride Hydrolases*
Cell Line
Chromosome Mapping
Chromosomes, Human, Pair 3 / genetics*
Cloning, Molecular
DNA, Complementary
Gene Expression
Genes, Tumor Suppressor*
Molecular Sequence Data
Neoplasm Proteins / genetics*
Polymerase Chain Reaction
Proteins / genetics*
Sequence Analysis, DNA
Reg. No./Substance:
0/DNA, Complementary; 0/Neoplasm Proteins; 0/Proteins; 0/fragile histidine triad protein; EC 3.6.-/Acid Anhydride Hydrolases

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