Document Detail


Identification of a novel developmental mechanism in the generation of mesothelia.
MedLine Citation:
PMID:  22764055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mesothelium is the surface layer of all coelomic organs and is crucial for the generation of their vasculature. Still, our understanding of the genesis of this essential cell type is restricted to the heart where a localized exogenous population of cells, the proepicardium, migrates to and envelops the myocardium supplying mesothelial, vascular and stromal cell lineages. Currently it is not known whether this pattern of development is specific to the heart or applies broadly to other coelomic organs. Using two independent long-term lineage-tracing studies, we demonstrate that mesothelial progenitors of the intestine are intrinsic to the gut tube anlage. Furthermore, a novel chick-quail chimera model of gut morphogenesis reveals these mesothelial progenitors are broadly distributed throughout the gut primordium and are not derived from a localized and exogenous proepicardium-like source of cells. These data demonstrate an intrinsic origin of mesothelial cells to a coelomic organ and provide a novel mechanism for the generation of mesothelial cells.
Authors:
Nichelle I Winters; Rebecca T Thomason; David M Bader
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-04
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  139     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-26     Completed Date:  2012-10-16     Revised Date:  2013-08-18    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  2926-34     Citation Subset:  IM    
Affiliation:
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Cell Lineage
Chick Embryo
Coturnix
Embryonic Stem Cells / cytology,  metabolism
Epithelial Cells / cytology,  metabolism
Epithelium / embryology*,  metabolism
Green Fluorescent Proteins / genetics,  metabolism
Intestines / cytology,  embryology*,  metabolism
Recombinant Proteins / genetics,  metabolism
Transplantation Chimera / embryology,  genetics,  metabolism
Grant Support
ID/Acronym/Agency:
CA68485/CA/NCI NIH HHS; DK20593/DK/NIDDK NIH HHS; DK58404/DK/NIDDK NIH HHS; DK59637/DK/NIDDK NIH HHS; EY08126/EY/NEI NIH HHS; HD15052/HD/NICHD NIH HHS; R01 DK83234/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 147336-22-9/Green Fluorescent Proteins
Comments/Corrections

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