| Identification of a novel developmental mechanism in the generation of mesothelia. | |
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MedLine Citation:
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PMID: 22764055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mesothelium is the surface layer of all coelomic organs and is crucial for the generation of their vasculature. Still, our understanding of the genesis of this essential cell type is restricted to the heart where a localized exogenous population of cells, the proepicardium, migrates to and envelops the myocardium supplying mesothelial, vascular and stromal cell lineages. Currently it is not known whether this pattern of development is specific to the heart or applies broadly to other coelomic organs. Using two independent long-term lineage-tracing studies, we demonstrate that mesothelial progenitors of the intestine are intrinsic to the gut tube anlage. Furthermore, a novel chick-quail chimera model of gut morphogenesis reveals these mesothelial progenitors are broadly distributed throughout the gut primordium and are not derived from a localized and exogenous proepicardium-like source of cells. These data demonstrate an intrinsic origin of mesothelial cells to a coelomic organ and provide a novel mechanism for the generation of mesothelial cells. |
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Authors:
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Nichelle I Winters; Rebecca T Thomason; David M Bader |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-07-04 |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-26 Completed Date: 2012-10-16 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 2926-34 Citation Subset: IM |
Affiliation:
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Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified Cell Lineage Chick Embryo Coturnix Embryonic Stem Cells / cytology, metabolism Epithelial Cells / cytology, metabolism Epithelium / embryology*, metabolism Green Fluorescent Proteins / genetics, metabolism Intestines / cytology, embryology*, metabolism Recombinant Proteins / genetics, metabolism Transplantation Chimera / embryology, genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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CA68485/CA/NCI NIH HHS; DK20593/DK/NIDDK NIH HHS; DK58404/DK/NIDDK NIH HHS; DK59637/DK/NIDDK NIH HHS; EY08126/EY/NEI NIH HHS; HD15052/HD/NICHD NIH HHS; R01 DK83234/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 147336-22-9/Green Fluorescent Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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