| Identification of the novel antimicrobial fatty acid (5Z,9Z)-14-methyl-5,9-pentadecadienoic acid in Eunicea succinea. | |
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MedLine Citation:
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PMID: 9170293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The phospholipid fatty acid composition of Eunicea succinea was investigated, and the novel (5Z,9Z)-14-methyl-5,9-pentadecadienoic acid was identified. Structural characterization was accomplished by means of mass spectrometry of its pyrrolidide derivative, NMR, FT1R, and total synthesis. Other interesting phospholipid fatty acids in E. succinea were the tetracosapolyenoic acids 6,9,12,15,18,21-tetracosahexaenoic acid (24:6) and 6,9,12,15,18-tetracosapentaenoic acids (24:5). The title compound was particularly active against Gram-positive bacteria such as Staphylococcus aureus (MIC 0.24 mumol/mL) and Streptococcus faecalis (MIC 0.16 mumol/ mL). |
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Authors:
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N M Carballeira; E D Reyes; A Sostre; A D Rodríguez; J L Rodríguez; F A González |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of natural products Volume: 60 ISSN: 0163-3864 ISO Abbreviation: J. Nat. Prod. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-07-03 Completed Date: 1997-07-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 502-4 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Puerto Rico, San Juan, Puerto Rico 00931. ncarball@upracd.upr.clu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / isolation & purification*, pharmacology Bacteria / drug effects Cnidaria / metabolism* Fatty Acids, Unsaturated / isolation & purification*, pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Spectroscopy, Fourier Transform Infrared |
| Grant Support | |
ID/Acronym/Agency:
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5G1-2RR03641/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/14-methyl-5,9-pentadecadienoic acid; 0/Anti-Bacterial Agents; 0/Fatty Acids, Unsaturated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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