Document Detail


Identification of a novel FGF, FGF-21, preferentially expressed in the liver.
MedLine Citation:
PMID:  10858549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus ( approximately 30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical ( approximately 75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar ( approximately 35% amino acid identity) to FGF-19.
Authors:
T Nishimura; Y Nakatake; M Konishi; N Itoh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1492     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-27     Completed Date:  2000-10-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
Affiliation:
Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida-Shimoadachi, Sakyo, Kyoto 606-8501,Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AB021975;  AB025718
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
DNA, Complementary / analysis
Embryo, Mammalian / physiology
Fibroblast Growth Factors / genetics*
Humans
Liver / metabolism*
Mice
Molecular Sequence Data
Phylogeny
Sequence Homology, Amino Acid
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/fibroblast growth factor 21; 62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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