| Identification of a novel Arabidopsis thaliana nitric oxide-binding molecule with guanylate cyclase activity in vitro. | |
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MedLine Citation:
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PMID: 21820435 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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While there is evidence of nitric oxide (NO)-dependent signalling via the second messenger cyclic guanosine 3',5'-monophosphate (cGMP) in plants, guanylate cyclases (GCs), enzymes that catalyse the formation of cGMP from guanosine 5'-triphosphate (GTP) have until recently remained elusive and none of the candidates identified to-date are NO-dependent. Using both a GC and heme-binding domain specific (H-NOX) search motif, we have identified an Arabidopsis flavin monooxygenase (At1g62580) and shown electrochemically that it binds NO, has a higher affinity for NO than for O(2) and that this molecule can generate cGMP from GTP in vitro in an NO-dependent manner. |
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Authors:
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Takalani Mulaudzi; Ndiko Ludidi; Oziniel Ruzvidzo; Monique Morse; Nicolette Hendricks; Emmanuel Iwuoha; Chris Gehring |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-31 |
Journal Detail:
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Title: FEBS letters Volume: - ISSN: 1873-3468 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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