Document Detail


Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3).
MedLine Citation:
PMID:  21669528     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A series of benzothiophene methyl amines were examined in an effort to identify non-amidine chemotypes with reduced polypharmacology from existing leads with the goal of finding potent ASIC3 channel blockers to advance the therapeutic evaluation of ASIC3 inhibition.
Authors:
Scott D Kuduk; Ronald K Chang; Christina N Di Marco; Robert M Dipardo; Sean P Cook; Matthew J Cato; Aneta Jovanovska; Mark O Urban; Michael Leitl; Robert H Spencer; Stefanie A Kane; George D Hartman; Mark T Bilodeau
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-27
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-6-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Affiliation:
Department of Medicinal Chemistry, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA.
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