Document Detail

Identification of neurocircuitry controlling cardiovascular function in humans using functional neurosurgery: implications for exercise control.
MedLine Citation:
PMID:  18567605     Owner:  NLM     Status:  MEDLINE    
The neurocircuitry underlying human cardiovascular control during exercise has yet to be fully elucidated. Functional imaging studies and animal studies have so far identified potential circuits that might be involved in the cardiovascular response to exercise, so-called 'central command'. This brief review highlights neurocircuits that may have functional significance as judged from direct recordings of electrical activity during exercise in patients with implanted deep brain stimulating electrodes. Of particular interest is the periaqueductal grey area (PAG), where electrodes are implanted in humans to treat chronic pain. This area is known to be important in the exercise pressor reflex in animals. Our studies have shown that changes occur in this region during anticipation of exercise, indicating a possible role in the central command of cardiovascular variables before and during exercise. This leads us to suggest that the PAG may be an 'integrating area' between the feedback signals from muscle and the feedforward signals from higher centres. The role of the PAG in cardiovascular control in humans, with reference to electrical stimulation experiments, is also described.
Alexander L Green; David J Paterson
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-06-20
Journal Detail:
Title:  Experimental physiology     Volume:  93     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-19     Completed Date:  2008-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1022-8     Citation Subset:  IM    
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK.
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MeSH Terms
Cardiovascular Physiological Phenomena
Cardiovascular System / innervation*
Deep Brain Stimulation
Exercise / physiology*
Feedback / physiology
Nerve Net / physiology
Periaqueductal Gray / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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