Document Detail

Identification of neuroanatomical substrates of set-shifting ability: evidence from patients with focal brain lesions.
MedLine Citation:
PMID:  18166388     Owner:  NLM     Status:  MEDLINE    
This work concerns the investigation of executive functions in patients with focal brain lesion. In order to identify the underlying substrates for executive functions, 54 patients with focal cortical (n=30), subcortical (n=13) and cerebellar damage (n=10) (M=9; F=1) in the age range of 24-65 years with a minimum of Class V education have been investigated. The patients were admitted to the Department of Neuromedicine of Bangur Institute of Neurology, Calcutta. Each patient with focal lesion was matched with a healthy normal subject controlling for age and education. The socio-economic background was also taken into consideration. Controls were selected from the families of other patients admitted to the institution and also from individuals who volunteered to act as controls. Here too, rigid criteria have been followed to select the normals. Mini Mental State Examination (MMSE) and General Health Questionnaire (GHQ) were administered to screen out the neurological and psychiatric abnormalities in selection of normal control and Wisconsin Card Sorting Test (WCST) was administered to find out the executive function, in terms of set-shifting ability. Since standard anatomical groupings can obscure more specific brain-behavior relations, group-comparison design does not always allow determination of the effective lesion responsible for a particular deficit (Godefroy et al., 1998). The Classification and Regression Tree (CART) analysis has been used to determine the brain-behavior relationships. The result reveals that the frontal lobes are essential determinants of set-shifting capacity. However, for optimal execution of set-shifting function, the frontal lobes require participation of other cortical, subcortical and cerebellar regions. The result has been discussed in the light of the existing theories and research reports.
Pritha Mukhopadhyay; Aparna Dutt; Shyamal Kumar Das; Arindam Basu; Avijit Hazra; Tapan Dhibar; Trishit Roy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in brain research     Volume:  168     ISSN:  0079-6123     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-01     Completed Date:  2008-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  95-104     Citation Subset:  IM    
Department of Psychology, University College of Science and Technology, 92 APC Road, Calcutta, India.
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MeSH Terms
Attention / physiology*
Brain Injuries / physiopathology*
Brain Mapping*
Case-Control Studies
Mental Status Schedule
Middle Aged
Neuropsychological Tests
Problem Solving / physiology*
Set (Psychology)*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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