Document Detail


Identification of a naturally occurring peroxidase-lipoxygenase fusion protein.
MedLine Citation:
PMID:  9302294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A distant relative of catalase that is specialized for metabolism of a fatty acid hydroperoxide was identified. This heme peroxidase occurs in coral as part of a fusion protein, the other component of which is a lipoxygenase that forms the hydroperoxide substrate. The end product is an unstable epoxide (an allene oxide) that is a potential precursor of prostaglandin-like molecules. These results extend the known chemistry of catalase-like proteins and reveal a distinct type of enzymatic construct involved in the metabolism of polyunsaturated fatty acids.
Authors:
R Koljak; O Boutaud; B H Shieh; N Samel; A R Brash
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  277     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-10     Completed Date:  1997-10-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1994-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF003692
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Arachidonic Acid / metabolism
Binding Sites
Catalase / chemistry
Catalysis
Cloning, Molecular
Cnidaria / enzymology*,  genetics
Hydrogen Peroxide / metabolism
Intramolecular Oxidoreductases*
Isomerases / chemistry
Lipoxygenase / chemistry*,  genetics,  isolation & purification,  metabolism
Molecular Sequence Data
Peroxidase / chemistry*,  genetics,  isolation & purification,  metabolism
Peroxidases / chemistry*,  isolation & purification,  metabolism
Recombinant Proteins / metabolism
Sequence Homology, Amino Acid
Grant Support
ID/Acronym/Agency:
GM49502/GM/NIGMS NIH HHS; TW00404/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 506-32-1/Arachidonic Acid; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.-/Peroxidases; EC 1.11.1.6/Catalase; EC 1.11.1.7/Peroxidase; EC 1.13.11.12/Lipoxygenase; EC 1.13.11.40/Allene oxide synthase-lipoxygenase protein, Plexaura homomalla; EC 5.-/Isomerases; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.99.6/hydroperoxide isomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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