| Identification of a naturally occurring peroxidase-lipoxygenase fusion protein. | |
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MedLine Citation:
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PMID: 9302294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A distant relative of catalase that is specialized for metabolism of a fatty acid hydroperoxide was identified. This heme peroxidase occurs in coral as part of a fusion protein, the other component of which is a lipoxygenase that forms the hydroperoxide substrate. The end product is an unstable epoxide (an allene oxide) that is a potential precursor of prostaglandin-like molecules. These results extend the known chemistry of catalase-like proteins and reveal a distinct type of enzymatic construct involved in the metabolism of polyunsaturated fatty acids. |
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Authors:
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R Koljak; O Boutaud; B H Shieh; N Samel; A R Brash |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 277 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-10-10 Completed Date: 1997-10-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1994-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF003692 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Arachidonic Acid / metabolism Binding Sites Catalase / chemistry Catalysis Cloning, Molecular Cnidaria / enzymology*, genetics Hydrogen Peroxide / metabolism Intramolecular Oxidoreductases* Isomerases / chemistry Lipoxygenase / chemistry*, genetics, isolation & purification, metabolism Molecular Sequence Data Peroxidase / chemistry*, genetics, isolation & purification, metabolism Peroxidases / chemistry*, isolation & purification, metabolism Recombinant Proteins / metabolism Sequence Homology, Amino Acid |
| Grant Support | |
ID/Acronym/Agency:
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GM49502/GM/NIGMS NIH HHS; TW00404/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 506-32-1/Arachidonic Acid; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.-/Peroxidases; EC 1.11.1.6/Catalase; EC 1.11.1.7/Peroxidase; EC 1.13.11.12/Lipoxygenase; EC 1.13.11.40/Allene oxide synthase-lipoxygenase protein, Plexaura homomalla; EC 5.-/Isomerases; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.99.6/hydroperoxide isomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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