| Identification of mouse MARVELD1 as a microtubule associated protein that inhibits cell cycle progression and migration. | |
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MedLine Citation:
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PMID: 21347699 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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MARVEL domain-containing 1 (MARVELD1) is a newly identified nuclear protein; however its function has not been clear until now. Here, we report that mouse MARVELD1 (mMARVELD1), which is highly conserved between mice and humans, exhibits cell cycle-dependent cellular localization. In NIH3T3 cells, MARVELD1 was observed in the nucleus and at the perinuclear region during interphase, but was localized at the mitotic spindle and midbody at metaphase, and a significant fraction of mMARVELD1 translocated to the plasma membrane during anaphase. In addition, treatment of cells with colchicine, a microtubuledepolymerizing agent, resulted in translocation of mMARVELD1 to the plasma membrane, and association of mMARVELD1 and α-tubulin was confirmed by co-immunoprecipitation. Finally, overexpression of mMARVELD1 resulted in a remarkable inhibition of cell proliferation, G1-phase arrest, and reduced cell migration. These findings indicate that mMARVELD1 is a microtubule-associated protein that plays an important role in cell cycle progression and migration. |
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Authors:
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Fanli Zeng; Yanyan Tian; Shuliang Shi; Qiong Wu; Shanshan Liu; Hongxia Zheng; Lei Yue; Yu Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-24 |
Journal Detail:
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Title: Molecules and cells Volume: - ISSN: 0219-1032 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610936 Medline TA: Mol Cells Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Life Science and Engineering, Harbin Institute of Technology, Harbin, 150001, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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