Document Detail


Identification of mouse MARVELD1 as a microtubule associated protein that inhibits cell cycle progression and migration.
MedLine Citation:
PMID:  21347699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MARVEL domain-containing 1 (MARVELD1) is a newly identified nuclear protein; however its function has not been clear until now. Here, we report that mouse MARVELD1 (mMARVELD1), which is highly conserved between mice and humans, exhibits cell cycle-dependent cellular localization. In NIH3T3 cells, MARVELD1 was observed in the nucleus and at the perinuclear region during interphase, but was localized at the mitotic spindle and midbody at metaphase, and a significant fraction of mMARVELD1 translocated to the plasma membrane during anaphase. In addition, treatment of cells with colchicine, a microtubule-depolymerizing agent, resulted in translocation of mMARVELD1 to the plasma membrane, and association of mMARVELD1 and α-tubulin was confirmed by co-immunoprecipitation. Finally, overexpression of mMARVELD1 resulted in a remarkable inhibition of cell proliferation, G1-phase arrest, and reduced cell migration. These findings indicate that mMARVELD1 is a microtubule-associated protein that plays an important role in cell cycle progression and migration.
Authors:
Fanli Zeng; Yanyan Tian; Shuliang Shi; Qiong Wu; Shanshan Liu; Hongxia Zheng; Lei Yue; Yu Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-24
Journal Detail:
Title:  Molecules and cells     Volume:  31     ISSN:  0219-1032     ISO Abbreviation:  Mol. Cells     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-28     Completed Date:  2011-09-26     Revised Date:  2014-02-26    
Medline Journal Info:
Nlm Unique ID:  9610936     Medline TA:  Mol Cells     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Brain / metabolism
Cell Membrane / metabolism
Cell Movement*
Cell Nucleus / metabolism
Cell Proliferation
Consensus Sequence
G1 Phase*
Membrane Proteins
Mice
Mice, Inbred C57BL
Microtubule-Associated Proteins / metabolism*
Microtubules / metabolism*
Molecular Sequence Data
Muscle, Skeletal / metabolism
NIH 3T3 Cells
Nuclear Proteins / metabolism*
Protein Transport
Recombinant Fusion Proteins / metabolism*
Sequence Homology, Amino Acid
Tubulin / metabolism*
Chemical
Reg. No./Substance:
0/MARVELD1 protein, mouse; 0/Membrane Proteins; 0/Microtubule-Associated Proteins; 0/Nuclear Proteins; 0/Recombinant Fusion Proteins; 0/Tubulin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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