|Identification of mouse MARVELD1 as a microtubule associated protein that inhibits cell cycle progression and migration.|
|PMID: 21347699 Owner: NLM Status: MEDLINE|
|MARVEL domain-containing 1 (MARVELD1) is a newly identified nuclear protein; however its function has not been clear until now. Here, we report that mouse MARVELD1 (mMARVELD1), which is highly conserved between mice and humans, exhibits cell cycle-dependent cellular localization. In NIH3T3 cells, MARVELD1 was observed in the nucleus and at the perinuclear region during interphase, but was localized at the mitotic spindle and midbody at metaphase, and a significant fraction of mMARVELD1 translocated to the plasma membrane during anaphase. In addition, treatment of cells with colchicine, a microtubule-depolymerizing agent, resulted in translocation of mMARVELD1 to the plasma membrane, and association of mMARVELD1 and α-tubulin was confirmed by co-immunoprecipitation. Finally, overexpression of mMARVELD1 resulted in a remarkable inhibition of cell proliferation, G1-phase arrest, and reduced cell migration. These findings indicate that mMARVELD1 is a microtubule-associated protein that plays an important role in cell cycle progression and migration.|
|Fanli Zeng; Yanyan Tian; Shuliang Shi; Qiong Wu; Shanshan Liu; Hongxia Zheng; Lei Yue; Yu Li|
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|Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-01-24|
|Title: Molecules and cells Volume: 31 ISSN: 0219-1032 ISO Abbreviation: Mol. Cells Publication Date: 2011 Mar|
|Created Date: 2011-03-28 Completed Date: 2011-09-26 Revised Date: 2014-02-26|
Medline Journal Info:
|Nlm Unique ID: 9610936 Medline TA: Mol Cells Country: United States|
|Languages: eng Pagination: 267-74 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Amino Acid Sequence
Brain / metabolism
Cell Membrane / metabolism
Cell Nucleus / metabolism
Mice, Inbred C57BL
Microtubule-Associated Proteins / metabolism*
Microtubules / metabolism*
Molecular Sequence Data
Muscle, Skeletal / metabolism
NIH 3T3 Cells
Nuclear Proteins / metabolism*
Recombinant Fusion Proteins / metabolism*
Sequence Homology, Amino Acid
Tubulin / metabolism*
|0/MARVELD1 protein, mouse; 0/Membrane Proteins; 0/Microtubule-Associated Proteins; 0/Nuclear Proteins; 0/Recombinant Fusion Proteins; 0/Tubulin|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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