Document Detail

Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death.
MedLine Citation:
PMID:  20298688     Owner:  NLM     Status:  MEDLINE    
Fas interaction at the plasma membrane with its lipid and protein environment plays a crucial role in the early steps of Fas signalling induced by Fas ligand binding. Particularly, Fas localisation in the raft nanodomains, ezrin-mediated interaction with the actin cytoskeleton and subsequent internalization are critical steps in Fas-mediated cell death. We identified a lysine-rich region (LRR) in the cytoplasmic, membrane-proximal region of Fas as a key determinant modulating these initial events. Through a genetic approach, we demonstrate that Fas LRR represents another signal additional to palmitoylation targeting Fas to the raft nanodomains, and modulates Fas interaction with the cytoskeleton.
Aur?lie Rossin; Rosana Kral; Nadia Lounnas; Krittalak Chakrabandhu; S?bastien Mailfert; Didier Marguet; Anne-Odile Hueber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-16
Journal Detail:
Title:  Experimental cell research     Volume:  316     ISSN:  1090-2422     ISO Abbreviation:  Exp. Cell Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1513-22     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Universit? de Nice Sophia-Antipolis, CNRS UMR 6543, Institute of Developmental Biology and Cancer Research, Equipe labelis?e La Ligue, Nice, France.
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MeSH Terms
Antigens, CD95 / genetics,  metabolism*
Cell Nucleus / metabolism
Cells, Cultured
Cytoskeletal Proteins / genetics,  metabolism
Cytoskeleton / metabolism
Fas Ligand Protein
Fluorescent Antibody Technique
Lysine / chemistry,  genetics,  metabolism*
Membrane Microdomains / metabolism*
Mutation / genetics
RNA, Messenger / genetics,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction*
T-Lymphocytes / metabolism
TNF-Related Apoptosis-Inducing Ligand / metabolism
Reg. No./Substance:
0/Antigens, CD95; 0/Cytoskeletal Proteins; 0/FAS protein, human; 0/Fas Ligand Protein; 0/Fas protein, mouse; 0/RNA, Messenger; 0/TNF-Related Apoptosis-Inducing Ligand; 0/ezrin; 56-87-1/Lysine

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