| Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death. | |
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MedLine Citation:
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PMID: 20298688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fas interaction at the plasma membrane with its lipid and protein environment plays a crucial role in the early steps of Fas signalling induced by Fas ligand binding. Particularly, Fas localisation in the raft nanodomains, ezrin-mediated interaction with the actin cytoskeleton and subsequent internalization are critical steps in Fas-mediated cell death. We identified a lysine-rich region (LRR) in the cytoplasmic, membrane-proximal region of Fas as a key determinant modulating these initial events. Through a genetic approach, we demonstrate that Fas LRR represents another signal additional to palmitoylation targeting Fas to the raft nanodomains, and modulates Fas interaction with the cytoskeleton. |
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Authors:
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Aur?lie Rossin; Rosana Kral; Nadia Lounnas; Krittalak Chakrabandhu; S?bastien Mailfert; Didier Marguet; Anne-Odile Hueber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-16 |
Journal Detail:
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Title: Experimental cell research Volume: 316 ISSN: 1090-2422 ISO Abbreviation: Exp. Cell Res. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373226 Medline TA: Exp Cell Res Country: United States |
Other Details:
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Languages: eng Pagination: 1513-22 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Universit? de Nice Sophia-Antipolis, CNRS UMR 6543, Institute of Developmental Biology and Cancer Research, Equipe labelis?e La Ligue, Nice, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD95 / genetics, metabolism* Apoptosis* Cell Nucleus / metabolism Cells, Cultured Cytoskeletal Proteins / genetics, metabolism Cytoskeleton / metabolism Fas Ligand Protein Fluorescent Antibody Technique Humans Immunoblotting Immunoprecipitation Lipoylation Lysine / chemistry, genetics, metabolism* Membrane Microdomains / metabolism* Mice Mutation / genetics RNA, Messenger / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction* T-Lymphocytes / metabolism TNF-Related Apoptosis-Inducing Ligand / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Cytoskeletal Proteins; 0/FAS protein, human; 0/Fas Ligand Protein; 0/Fas protein, mouse; 0/RNA, Messenger; 0/TNF-Related Apoptosis-Inducing Ligand; 0/ezrin; 56-87-1/Lysine |
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