Document Detail

Identification and localization of netrin-4 and neogenin in human first trimester and term placenta.
MedLine Citation:
PMID:  22705235     Owner:  NLM     Status:  Publisher    
We describe here for the first time the characterization of family member of netrins, netrin-4 and its receptor neogenin, during the development of the placenta. By using western blots and RT-PCR, we demonstrated the presence of netrin-4 and its receptor neogenin protein as well as their transcripts. Using immunohistochemistry, we studied the distribution of netrin-4 and neogenin in both the first trimester and term placenta. We observed staining of netrin-4 in villous and extravillous cytotrophoblasts, syncytiotrophoblast, and endothelial cells whereas staining in stromal cells was faint. In decidua, we observed netrin-4 labelling in glandular epithelial cells, perivascular decidualized cells, and endothelial cells. However, neogenin was absent in villous and extravillous cytotrophoblasts and was expressed only on syncytiotrophoblast and placental stromal cells in the first trimester and at term placenta. The pattern of distribution suggests that a functional netrin-4-neogenin pathway might be restricted to syncytiotrophoblasts, mesenchymal cells, and villous endothelial cells. This pathway function might vary with its localization in the placenta. It is possibly involved in angiogenesis, morphogenesis, and differentiation.
M Dakouane-Giudicelli; C Duboucher; J Fortemps; S Salama; A Brulé; P Rozenberg; P de Mazancourt
Related Documents :
22851545 - Endothelium-selective activation of amp-activated protein kinase prevents diabetes-indu...
12689765 - Synaptic cell adhesion goes functional.
20592225 - Vip promotes resistance in the pseudomonas aeruginosa-infected cornea by modulating adh...
9094615 - Host cell-dependent alterations in envelope components of human immunodeficiency virus ...
23227165 - Intravenous ferric chloride hexahydrate supplementation induced endothelial dysfunction...
11544025 - Leukocyte transendothelial migration: orchestrating the underlying molecular machinery.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-15
Journal Detail:
Title:  Placenta     Volume:  -     ISSN:  1532-3102     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
UPRES EA2493, Université de Versailles St-Quentin, PRES Universud Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Collagen I confers gamma radiation resistance.
Next Document:  CDKN1C/P57 Is Regulated by the Notch Target Gene Hes1 and Induces Senescence in Human Hepatocellular...