Document Detail

Identification of lactoferrin as a human dedifferentiation factor through the studies of reptile tissue regeneration mechanisms.
MedLine Citation:
PMID:  24633229     Owner:  NLM     Status:  Publisher    
In this study, we performed 2-dimensional electrophoresis with protein extracts from the lizard tails, and analyzed the protein expression profiles during the tissue regeneration to identify the dedifferentiation factor. As a result, we identified 18 protein spots among total of 292 spots, of which proteins expression were specifically expressed during blastema formation. We selected lactoferrin as a candidate because it is the mammalian homologue of leech-derived tryptase inhibitor, which showed the highest frequency among the 18 proteins. Lactoferrin was specifically expressed in various stem cell lines, and enhanced the efficiency of iPSC generation upto approximately 7-fold relative to the control. Furthermore, lactoferrin increased the efficiency by 2-fold without enforced expression of Klf4. These results suggest that lactoferrin may induce dedifferentiation at least partly by increasing the expression of Klf4.
Kil Soo Bae; Sun Young Kim; Soon Yong Park; Ae Jin Jeong; Hyun Hee Lee; Jungwoon Lee; Yee Sook Cho; Sun-Hee Leem; Tae-Hong Kang; Kwang-Hee Bae; Jae-Ho Kim; Yong Woo Jung; Woojin Jun; Suk Ran Yoon; Sang-Chul Lee; Jin Woong Chung
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-13
Journal Detail:
Title:  Journal of microbiology and biotechnology     Volume:  -     ISSN:  1738-8872     ISO Abbreviation:  J. Microbiol. Biotechnol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431852     Medline TA:  J Microbiol Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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