| Identification of interferon-beta antibodies in a reference laboratory setting: findings for 1144 consecutive sera. | |
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MedLine Citation:
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PMID: 17889376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical studies demonstrate differences in interferon-beta (IFNbeta) antibody detection frequencies among multiple sclerosis patients receiving different IFNbeta products. We sought to determine if these differences are also found when IFNbeta antibodies are measured in a reference laboratory, where factors normally controlled in clinical studies are unknown. Serum IFNbeta binding antibodies (BAbs) were quantitated by ELISA; BAbs-positive samples were then tested in a bioassay for neutralizing antibodies (NAbs). Consistent with clinical studies, frequencies of BAbs-positive sera and NAbs-positive sera were lower in the Avonex (IFNbeta-1a) treatment group than Rebif (IFNbeta-1a) and Betaseron (IFNbeta-1b) groups. We further identified a predictive relationship between positive BAbs levels and NAbs activity in patients treated with IFNbeta-1a products, but not those treated with IFNbeta-1b. |
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Authors:
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Harry E Prince; Mary Lapé-Nixon; Carol Audette; Kenneth Van Horn |
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Publication Detail:
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Type: Journal Article Date: 2007-09-21 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 190 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-30 Completed Date: 2007-12-21 Revised Date: 2008-07-03 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 165-9 Citation Subset: IM |
Affiliation:
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Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA 90630, USA. hprince@focusdx.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
/
analysis*,
blood,
immunology* Biological Assay / methods* Enzyme-Linked Immunosorbent Assay Humans Interferon-beta / immunology* Multiple Sclerosis / drug therapy* Predictive Value of Tests Protein Binding / immunology Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 145155-23-3/interferon beta-1b; 145258-61-3/interferon beta 1a; 77238-31-4/Interferon-beta |
| Comments/Corrections | |
Comment In:
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J Neuroimmunol. 2008 Feb;194(1-2):5-6
[PMID:
18031830
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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