| Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer tissue. | |
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MedLine Citation:
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PMID: 8188079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to test if specific insulin and insulin-like growth factor I (IGF I) receptors are expressed in ovarian cancer tissue. Thirteen tissue specimens from primary ovarian cancers, 1 specimen from a primary peritoneal carcinoma, 10 specimens from metastatic lesions of ovarian carcinomas, and 4 specimens from recurrent ovarian cancers together with 13 normal ovaries were tested for their content of insulin and IGF-I receptors, by the application of specific insulin and IGF-I receptor radioimmunoassays. The insulin receptor (IR) and IGF-I receptor (IGF R) content in the primary tumors varied between 23.8-321.4 and 16.4-554.2 ng/0.1 mg DNA, respectively. Metastatic lesions contained between 12.3 and 226.7 ng IR/0.1 mg DNA and between 7.5 and 459.4 ng IGF R/0.1 mg DNA. In recurrent tumors the receptor concentrations were in the range of 41.5-79.8 and 48.9-160.9 ng/0.1 mg DNA for insulin and IGF-I receptors, respectively. Normal ovarian tissue contained between 12.2 and 150.1 ng IR and between 21.4 and 420.1 ng IGF R per 0.1 mg DNA, respectively. As both insulin and IGF-I receptors are present in ovarian cancer tissue, the effects of insulin and IGF-I as potential growth factors in ovarian cancer should be further investigated. |
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Authors:
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E P Beck; P Russo; B Gliozzo; W Jaeger; V Papa; L Wildt; V Pezzino; N Lang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gynecologic oncology Volume: 53 ISSN: 0090-8258 ISO Abbreviation: Gynecol. Oncol. Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-06-17 Completed Date: 1994-06-17 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 196-201 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynecology, University of Erlangen-Nuremberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Middle Aged Ovarian Neoplasms / chemistry* Ovary / chemistry Radioimmunoassay Receptor, IGF Type 1 / analysis* Receptor, Insulin / analysis* Reference Values |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Receptor, IGF Type 1; EC 2.7.10.1/Receptor, Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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