Document Detail

Identification of infants with major cognitive delay using parental report.
MedLine Citation:
PMID:  22188172     Owner:  NLM     Status:  Publisher    
Aim  The collection of data on longer-term neurodevelopmental outcomes within large neonatal randomized controlled trials by trained assessors can greatly increase costs and present many operational difficulties. The aim of this study was to develop a more practical alternative for identifying major cognitive delay in infants at the age of 24 months, based on parental reports. Method  A sample of 476 infants (206 female, 270 male) previously diagnosed with neonatal sepsis (mean birthweight 1329g [SD 865g], mean gestational age at birth 28.7wks [SD 4.5wks]) from the International Neonatal Immunotherapy Study were assessed using the Parent Report of Children's Abilities - Revised and the Bayley Scales of Infant Development, 2nd edition. Logistic regression was used to model the association between the risk of major cognitive delay (i.e. Bayley Scales of Infant Development Mental Development Index <55) and the Parent Report of Children's Abilities - Revised data. Results  The receiver operating characteristic curves for a number of predictive models were constructed - each achieved an area under the curve of at least 90%. The sensitivity, specificity, positive predictive value, and negative predictive value of a number of points on the receiver operating characteristic curves are presented. Interpretation  The Parent Report of Children's Abilities - Revised is a practical tool for identifying major cognitive delay in infants at 24 months.
Andrew J Martin; Brian A Darlow; Alison Salt; Wendy Hague; Lucille Sebastian; Kristy Mann; William Tarnow-Mordi;
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-21
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  -     ISSN:  1469-8749     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© The Authors. Developmental Medicine & Child Neurology © 2011 Mac Keith Press.
 National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.  Department of Paediatrics, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand.  Neurodisability Service, Great Ormond Street Hospital for Children NHS Trust and UCL Institute of Child Health, London, UK.  Westmead International Network for Neonatal Education and Research, Westmead Hospital and NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.
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