Document Detail

Identification of infants at risk for infantile spasms by neonatal polygraphy.
MedLine Citation:
PMID:  3434713     Owner:  NLM     Status:  MEDLINE    
Reevaluation of neonatal EEGs and polygraphic tracings of 40 infants with infantile spasms and/or hypsarrhythmia resulted in the constitution of a compound score for the identification of infants at risk for infantile spasms by neonatal EEG. The score comprises 8 distinct items: 2 concern behavioral characteristics, 6 abnormality of EEG background activity and paroxysmal events. A tracing registered at conceptional age 36 to 44 weeks (eventually up to 50 weeks) presenting at least 4 of these 8 items is scored positive for the risk of evolving hypsarrhythmia. In a prospective study the polygraphic tracings of 941 newborn infants were evaluated for risk: 18 infants suffering from perinatal distress and 7 newborns with malformations of the brain were scored positive and all 25 developed infantile spasms and/or hypsarrhythmia. One infant with later infantile spasms was missed by the scoring system. None of the remaining infants scored negative manifested infantile spasms. Thus, correct positive prognostication was 100% and false negative 0.1%. By conventional EEG 5 out of 8 patients with infantile spasms were correctly predicted. The high validity of the risk-score based on polygraphic tracing between conceptional age 36 to 44 weeks may allow pre-onset treatment preventing secondary mental deterioration due to hypsarrhythmia and infantile spasms.
B Walther; T Schmitt; B Reitter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  9     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  1987  
Date Detail:
Created Date:  1988-03-15     Completed Date:  1988-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  377-90     Citation Subset:  IM    
Department of Pediatrics, University Hospital, Mainz, West Germany.
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MeSH Terms
Prospective Studies
Retrospective Studies
Risk Factors
Sleep / physiology
Sleep, REM / physiology
Spasms, Infantile / diagnosis,  etiology*,  physiopathology

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