| Identification and in vitro immunosuppressive activity of a SDZ-IMM-125 metabolite isolated from phenobarbital-induced rabbit liver microsomes. | |
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MedLine Citation:
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PMID: 9381734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. A metabolite of D-serine-cyclosporine A has been isolated from phenobarbital induced rabbit liver microsomes using hplc. 2. This metabolite was identified by FAB, electrospray mass spectrometry as well as nmr spectroscopy and is the result of metabolism of the vinylic methyl group of the 9-carbon amino acid unique to the cyclosporins, the first amino acid of this cyclic undecapeptide. This metabolite exhibits a significantly lower immunosuppressive activity than IMM-125 and CsA. |
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Authors:
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R Dieden; R K Verbeeck; N Maton; D Latinne; G J Lhoëst |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 27 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-11-07 Completed Date: 1997-11-07 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 933-49 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, Laboratory of Mass Spectrometry, Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, High Pressure Liquid Cyclosporins / metabolism*, pharmacology* Immunosuppressive Agents / chemistry, metabolism*, pharmacology* Magnetic Resonance Spectroscopy Male Microsomes, Liver / drug effects*, metabolism* Phenobarbital / pharmacology* Rabbits Spectrometry, Mass, Fast Atom Bombardment |
| Chemical | |
Reg. No./Substance:
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0/Cyclosporins; 0/IMM 125; 0/Immunosuppressive Agents; 50-06-6/Phenobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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