Document Detail

Identification of an immunosuppressive factor in pregnancy serum.
MedLine Citation:
PMID:  781575     Owner:  NLM     Status:  MEDLINE    
Complement-inactivated allogeneic serum was found to contain a factor capable of suppressing BCG-induced inhibition of leukocyte migration in vitro. Although serum from late pregnancy was the most potent in this context, the ability to antagonize the leukocyte response appears to be an intrinsic property of human serum. The inhibitory factor was purified by salf fractionation and gel chromatography and the effect found to be associated with alpha-globulins of high lipid content which are probably alpha-lipoproteins. Estrogens, progesterone, or corticosteroids, associated with the lipoprotein, did not appear to be the cause of the observed suppression. The factor appears to block the immune response at the level of the lymphocyte and its nonspecific immunosuppressive properties could contribute to acceptance of the fetus by the mother.
W H Stimson; J C Blackstock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  48     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-10-01     Completed Date:  1976-10-01     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  AIM; IM    
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MeSH Terms
BCG Vaccine
Immunity, Cellular*
Immunologic Techniques
Leukocytes / immunology
Macrophage Migration-Inhibitory Factors
Mycobacterium bovis
Reg. No./Substance:
0/BCG Vaccine; 0/Macrophage Migration-Inhibitory Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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