Document Detail

Identification of human-specific adaptation sites of ATP6.
MedLine Citation:
PMID:  15965056     Owner:  NLM     Status:  MEDLINE    
Mitochondria play an essential role in forming ATP and generating heat. The proportion of these two depends on the coupling efficiency of electrochemical gradient to synthesize ATP. Therefore, an increased basal metabolic rate caused by partial uncoupling of the mitochondria can be balanced by a high caloric intake provided by a high-fat diet. The recent study by Mishmar et al. (Proc. Natl. Acad. Sci. USA 2003; 100: 171-176) suggested that ATP6 was the most variable gene among human mitochondrial DNAs and probably resulted from the adaptation of Homo sapiens to the colder climate during the migration out of Africa. According to this adaptation theory, the ATP6 of Homo sapiens (omnivorous animals consuming fat-containing diet) should be significantly different from that of other primates for permitting human adaptation to the dietary conditions. On the basis of this rationale, we analyzed ATP6 sequences of 136 unrelated Taiwanese subjects, which then were compared with 1,130 reported sequences. The obtained human consensus from 1,266 individuals was compared with that derived from 42 species of primates other than human. The alignment showed that human ATP6 harbored 80 variable residues, among which 25 amino acids were conserved in other primates, suggesting that adaptation constraints operating at the amino acid level results in the species-specific difference of ATP6. Therefore, these 25 amino acids are probably the human-specific adaptation residues of ATP6.
Bey-Liing Mau; Horng-Mo Lee; Chin-Yuan Tzen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1042     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-20     Completed Date:  2006-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-7     Citation Subset:  IM    
Division of General Internal Medicine, Sun Yat-Sen Cancer Center, Taipei 251, Taiwan.
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MeSH Terms
Adaptation, Biological / genetics*
Adenosine Triphosphatases / chemistry,  classification,  genetics*
Amino Acid Sequence
Conserved Sequence
Molecular Sequence Data
Polymorphism, Genetic / genetics
Reg. No./Substance:
EC 3.6.1.-/Adenosine Triphosphatases

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