Document Detail


Identification of human immunodeficiency virus-infected individuals by delayed type hypersensitivity skin testing.
MedLine Citation:
PMID:  9784827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if more useful information could be derived from delayed type hypersensitivity skin testing of human immunodeficiency virus (HIV)-infected patients by measuring the amount of induration in response to skin testing in contrast to assessing for the presence of anergy. DESIGN: Prospective, double-blind trial. SETTING: Two HIV clinics. PATIENTS: A sample of 60 ambulatory, HIV-infected patients and 18 normal controls. INTERVENTIONS: Delayed type hypersensitivity skin testing with a panel of recall antigens. MAIN OUTCOME MEASURES: Anergy, total induration in response to the panel of antigens, and CD4 lymphocyte count. RESULTS: Anergy was present in only 28 of 60 (46.7 percent) HIV-infected subjects. A low skin test score (under 20 mm of total induration) was present in 43 of 60 (71.7 percent) HIV-infected subjects (p < 0.01 vs anergy). One control patient was anergic, while two had a low skin test score (p = NS). Among HIV-infected subjects, there was poor correlation between CD4 lymphocyte count and skin test score (R2 = 0.12). CONCLUSIONS: Skin testing by this method identifies more HIV-infected patients than does assessing the presence or absence of anergy.
Authors:
M L Metersky; P Yang; H S Nielsen; A Catanzaro
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  28     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1998-12-07     Completed Date:  1998-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  272-9     Citation Subset:  IM; X    
Affiliation:
Pulmonary Division, University of Connecticut School of Medicine, Farmington 06030, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
CD4 Lymphocyte Count
Clonal Anergy
Double-Blind Method
Female
HIV Infections / diagnosis*,  immunology
Humans
Intradermal Tests*
Male
Prospective Studies
Regression Analysis
Grant Support
ID/Acronym/Agency:
MO1-RR00827/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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