| Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome. | |
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MedLine Citation:
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PMID: 22123317 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Syncope in Brugada syndrome (BS) patients is usually associated with ventricular tachyarrhythmia, but some episodes of syncope can be related to autonomic disorders. OBJECTIVE: The purpose of this study was to investigate the characteristics of syncope to differentiate high-risk syncope episodes from low-risk events in patients with BS. METHODS: We studied 84 patients with type 1 ECG and syncope. Patients were divided into two groups: patients with prodrome (Prodromal group, n = 41) and patients without prodrome (Non-prodromal group, n = 43). RESULTS: Ventricular fibrillation (VF) was documented at index event in 19 patients: 4 patients (21%) with documented VF experienced a prodrome prior to the onset of VF, whereas 15 patients (79%) did not have symptoms prior to documented VF (p<0.01). Twenty-seven patients in the Prodromal group and 7 patients in the Non-prodromal group were considered to have syncope related to autonomic dysfunction. Syncope in the other patients was defined as unexplained syncope. During the follow-up period (48 ± 48 months), recurrent syncope due to VF occurred in 13 patients among patients with only unexplained syncope and was more frequent in the Non-prodromal group (n = 10) than in the Prodromal group (n = 3; P = 0.044). In multivariate analysis, blurred vision (hazard ratio [HR], 0.20) and abnormal respiration (HR, 2.18) and fragmented QRS (HR, 2.39) were independently associated with the occurrence of VF. CONCLUSION: Syncope with prodrome, especially blurred vision, suggests a benign etiology of syncope in patients with BS. |
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Authors:
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Yutaka Take; Hiroshi Morita; Norihisa Toh; Nobuhiro Nishii; Satoshi Nagase; Kazufumi Nakamura; Kengo F Kusano; Tohru Ohe; Hiroshi Ito |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-25 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: - ISSN: 1556-3871 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 700-8558, Okayama, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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