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Identification of high-risk syncope related to ventricular fibrillation in patients with Brugada syndrome.
MedLine Citation:
PMID:  22123317     Owner:  NLM     Status:  Publisher    
BACKGROUND: Syncope in Brugada syndrome (BS) patients is usually associated with ventricular tachyarrhythmia, but some episodes of syncope can be related to autonomic disorders. OBJECTIVE: The purpose of this study was to investigate the characteristics of syncope to differentiate high-risk syncope episodes from low-risk events in patients with BS. METHODS: We studied 84 patients with type 1 ECG and syncope. Patients were divided into two groups: patients with prodrome (Prodromal group, n = 41) and patients without prodrome (Non-prodromal group, n = 43). RESULTS: Ventricular fibrillation (VF) was documented at index event in 19 patients: 4 patients (21%) with documented VF experienced a prodrome prior to the onset of VF, whereas 15 patients (79%) did not have symptoms prior to documented VF (p<0.01). Twenty-seven patients in the Prodromal group and 7 patients in the Non-prodromal group were considered to have syncope related to autonomic dysfunction. Syncope in the other patients was defined as unexplained syncope. During the follow-up period (48 ± 48 months), recurrent syncope due to VF occurred in 13 patients among patients with only unexplained syncope and was more frequent in the Non-prodromal group (n = 10) than in the Prodromal group (n = 3; P = 0.044). In multivariate analysis, blurred vision (hazard ratio [HR], 0.20) and abnormal respiration (HR, 2.18) and fragmented QRS (HR, 2.39) were independently associated with the occurrence of VF. CONCLUSION: Syncope with prodrome, especially blurred vision, suggests a benign etiology of syncope in patients with BS.
Yutaka Take; Hiroshi Morita; Norihisa Toh; Nobuhiro Nishii; Satoshi Nagase; Kazufumi Nakamura; Kengo F Kusano; Tohru Ohe; Hiroshi Ito
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-25
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  -     ISSN:  1556-3871     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 700-8558, Okayama, Japan.
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