Document Detail


Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR.
MedLine Citation:
PMID:  9469716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The peak at 3.35 ppm in the 1H-NMR spectrum characteristic for scyllo-inositol may be a marker for cerebral pathology, although it has a well-known constant concentration relative to myo-inositol. Such a peak was observed with an intensity at least 300% above normal in the brain of a healthy volunteer. The scyllo-inositol signal was assigned based on the detection of a corresponding peak at 74.5 ppm in the 13C-NMR spectrum and on the demonstration of singlet characteristics of the proton signal. The presence of substantial brain concentrations of scyllo-inositol suggests that scyllo-inositol metabolism may be regulated independently from myo-inositol and that such concentrations are compatible with normal health.
Authors:
E R Seaquist; R Gruetter
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  39     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-24     Completed Date:  1998-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  313-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / metabolism*
Brain Chemistry
Humans
Inositol / metabolism*
Magnetic Resonance Spectroscopy / diagnostic use*
Male
Stereoisomerism
Grant Support
ID/Acronym/Agency:
M01RR00400/RR/NCRR NIH HHS; RR08079/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
488-59-5/scyllitol; 6917-35-7/Inositol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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