| Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR. | |
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MedLine Citation:
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PMID: 9469716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The peak at 3.35 ppm in the 1H-NMR spectrum characteristic for scyllo-inositol may be a marker for cerebral pathology, although it has a well-known constant concentration relative to myo-inositol. Such a peak was observed with an intensity at least 300% above normal in the brain of a healthy volunteer. The scyllo-inositol signal was assigned based on the detection of a corresponding peak at 74.5 ppm in the 13C-NMR spectrum and on the demonstration of singlet characteristics of the proton signal. The presence of substantial brain concentrations of scyllo-inositol suggests that scyllo-inositol metabolism may be regulated independently from myo-inositol and that such concentrations are compatible with normal health. |
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Authors:
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E R Seaquist; R Gruetter |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 39 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-24 Completed Date: 1998-03-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 313-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Minnesota Medical School, Minneapolis, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / metabolism* Brain Chemistry Humans Inositol / metabolism* Magnetic Resonance Spectroscopy / diagnostic use* Male Stereoisomerism |
| Grant Support | |
ID/Acronym/Agency:
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M01RR00400/RR/NCRR NIH HHS; RR08079/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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488-59-5/scyllitol; 6917-35-7/Inositol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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