Document Detail

Identification of hibernating myocardium by dobutamine stress echocardiography: comparison with thallium-201 reinjection imaging.
MedLine Citation:
PMID:  7661075     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine the diagnostic value of dobutamine stress echocardiography (DSE) in the identification of hibernating myocardium and to compare its predictive accuracy with that of thallium-201 reinjection (RI) imaging. The subjects were 26 patients with wall motion abnormalities related to stenosed coronary arteries. DSE predicted postrevascularization improvement in 31 of 33 segments that were considered to be hibernating and identified 8 of 10 nonhibernating segments. In contrast, thallium-201 scintigraphy predicted all 33 hibernating segments when a post-RI myocardial thallium uptake in ischemic areas of > or = 50% of the maximum count in normal segments was used as a positive marker of myocardial viability. However, thallium studies predicted only 30 of 33 hibernating segments when thallium redistribution (RD) was used as a marker of viability in delayed or RI images. Among the 10 nonhibernating segments, an uptake of < 50% was observed in 4 segments and negative thallium-201 RD was observed in 5 segments. The sensitivity, specificity, and predictive values (PV) of DSE were 94%, 80%, positive PV 94%, and negative PV 80%, respectively. In contrast, the sensitivity, specificity, and PV of thallium-201 RI imaging were 100%, 40%, 85%, and 100% with uptake > or = 50% and 91%, 50% 86%, and 63% with RD, respectively. These results suggest that DSE may be useful for identifying hibernating myocardium and could therefore be helpful in selecting candidates for coronary revascularization.
T Haque; T Furukawa; M Takahashi; M Kinoshita
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  130     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-04     Completed Date:  1995-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-63     Citation Subset:  AIM; IM    
First Department of Internal Medicine, Shiga University of Medical Science, Japan.
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MeSH Terms
Chronic Disease
Coronary Disease / radionuclide imaging,  ultrasonography
Dobutamine / diagnostic use*
Echocardiography / instrumentation,  methods*
Exercise Test / methods*
Follow-Up Studies
Heart / radionuclide imaging*
Middle Aged
Myocardial Ischemia / radionuclide imaging*,  ultrasonography*
Prospective Studies
Sensitivity and Specificity
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed / instrumentation,  methods
Reg. No./Substance:
0/Thallium Radioisotopes; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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