Document Detail

Identification of heptanal and nonanal in bronchoalveolar lavage from rats exposed to low levels of ozone.
MedLine Citation:
PMID:  1417836     Owner:  NLM     Status:  MEDLINE    
Heptanal and nonanal are identified from in vitro studies as potential biomarkers of exposure to ozone, the former resulting from ozonation of palmitoleic acid and the latter from oleic acid. An analytical method is developed based on derivatization using O-pentafluorobenzylhydroxylamine HCl and gas chromatography. These molecules also are present in the lung lavage of Sprague-Dawley rats exposed to 1.3 ppm ozone for 10 hr. These results suggest aldehydes may be useful dosimeters for ozone and indicate that unsaturated fatty acids in the lung lining fluid layer undergo ozonation in vivo.
R Cueto; G L Squadrito; E Bermudez; W A Pryor
Related Documents :
22252536 - N-hexyl laurate and fourteen related fatty acid esters: new secretory compounds from th...
7119746 - The mycolic acids of mycobacterium chelonei.
2784406 - Purification of murine igg monoclonal antibodies by precipitation with caprylic acid: c...
17152096 - Optimization of phosphopeptide elution conditions in immobilized fe(iii) affinity chrom...
11320416 - Citric and gluconic acid production from fig by aspergillus niger using solid-state fer...
975616 - Tachycardia in spontaneously hypertensive and normotensive rats after fusaric acid and ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  188     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-19     Completed Date:  1992-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Biodynamics Institute, Louisiana State University, Baton Rouge 70803-1800.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aldehydes / analysis*
Biological Markers
Bronchoalveolar Lavage Fluid / metabolism*
Chromatography, Gas
Fatty Acids, Monounsaturated*
Gas Chromatography-Mass Spectrometry
Oleic Acid
Oleic Acids / metabolism
Ozone / pharmacology*
Palmitic Acids / metabolism
Pulmonary Surfactants / isolation & purification
Rats, Sprague-Dawley
Reg. No./Substance:
0/Aldehydes; 0/Biological Markers; 0/Fatty Acids, Monounsaturated; 0/Oleic Acids; 0/Palmitic Acids; 0/Pulmonary Surfactants; 10028-15-6/Ozone; 111-71-7/heptanal; 112-80-1/Oleic Acid; 124-19-6/nonanal; 2091-29-4/palmitoleic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Differential regulation of putrescine uptake in Trypanosoma cruzi and other trypanosomatids.
Next Document:  Hormonal and nutritional stimuli modulate apolipoprotein B mRNA editing in mouse liver.