Document Detail

Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver.
MedLine Citation:
PMID:  17326146     Owner:  NLM     Status:  MEDLINE    
Hepatocyte function and regeneration are severely compromised in severe liver disease, and a common sequela is cirrhosis. Structural changes caused by cirrhosis create a cellular environment conducive to the formation of ductular reactions (DRs). Ductular reactions are primarily composed of oval cells also known as "intermediate hepatobiliary cells". We have conducted single, double, and triple staining to study lineages of oval cells present in DRs. Staining with NCAM, CK19, and HepPar1 has revealed a distinctly bipolar structure to DRs that are embedded in cirrhotic tissue. Spatial analysis of cells that are singly HepPar1-positive, or CK19-positive, has revealed hepatocytic and biliary poles, respectively, in the DRs. Also, the location of singly NCAM-positive cells in DRs suggests that they may be bipotent liver stem/progenitor cells. The locations of other intermediate hepatobiliary cells, which have combinations of markers, suggest that CK19+/NCAM+ cells are transitional cells in the biliary lineage and that rare cells that are negative for all three markers are transitional cells in the hepatocytic lineage. A working cell lineage model for DRs is presented.
Hongchao Zhou; Leslie E Rogler; Lewis Teperman; Glyn Morgan; Charles E Rogler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  45     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  716-24     Citation Subset:  IM    
Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
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MeSH Terms
Antibodies / metabolism
Bile Ducts / metabolism,  pathology*
Cell Lineage*
Hepatocytes / metabolism,  pathology*
Liver Cirrhosis / metabolism,  pathology*
Liver Regeneration / physiology
Neural Cell Adhesion Molecules / immunology,  metabolism
Proteins / immunology,  metabolism
Stem Cells / metabolism,  pathology*
Reg. No./Substance:
0/Antibodies; 0/Neural Cell Adhesion Molecules; 0/Proteins

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