Document Detail

Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1.
MedLine Citation:
PMID:  14514779     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The hallmark of neurofibromatosis type 1 (NF1) is the development of multiple neurofibromas. Solitary neurofibroma may occur in an individual who does not have NF1, but multiple neurofibromas tend to develop only in those with NF1. It has been suggested that hormones may influence the neurofibromas of patients with NF1. The evidence that hormones may influence the growth of neurofibromas comes mainly from the observation that localised neurofibromas of patients with NF1 commonly grow during puberty and pregnancy. Because growth hormone (GH) concentrations increase during puberty, it is possible that GH influences the growth of these tumours.
AIMS: To investigate the presence of GH receptors (GHRs) in neurofibromas.
METHODS: By means of immunohistochemistry, the presence of GHRs was investigated in two groups of patients: 16 patients without NF1 with solitary neurofibromas (group A) and 10 patients with NF1 with localised neurofibromas (group B).
RESULTS: Six of the 16 patients in group A had neurofibromas that were immunopositive for GHR, whereas nine of the 10 patients in group B were immunopositive.
CONCLUSIONS: Most patients with NF1 have localised neurofibromas that express GHR. This suggests that GH may play some role in the development of localised neurofibromas in patients with NF1.
K S G Cunha; E P Barboza; E C Da Fonseca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  56     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-29     Completed Date:  2003-11-10     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  758-63     Citation Subset:  AIM; IM    
Federal Fluminense University, Medicine School, Pathology Department, Niterói, Rio de Janeiro, Brazil.
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MeSH Terms
Growth Disorders / complications,  drug therapy
Growth Hormone / contraindications
Immunohistochemistry / methods
Neurofibroma / chemistry
Neurofibromatosis 1 / complications,  metabolism*
Receptors, Somatotropin / analysis*
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Receptors, Somatotropin; 0/Tumor Markers, Biological; 9002-72-6/Growth Hormone

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