| Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. | |
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MedLine Citation:
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PMID: 14514779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The hallmark of neurofibromatosis type 1 (NF1) is the development of multiple neurofibromas. Solitary neurofibroma may occur in an individual who does not have NF1, but multiple neurofibromas tend to develop only in those with NF1. It has been suggested that hormones may influence the neurofibromas of patients with NF1. The evidence that hormones may influence the growth of neurofibromas comes mainly from the observation that localised neurofibromas of patients with NF1 commonly grow during puberty and pregnancy. Because growth hormone (GH) concentrations increase during puberty, it is possible that GH influences the growth of these tumours. AIMS: To investigate the presence of GH receptors (GHRs) in neurofibromas. METHODS: By means of immunohistochemistry, the presence of GHRs was investigated in two groups of patients: 16 patients without NF1 with solitary neurofibromas (group A) and 10 patients with NF1 with localised neurofibromas (group B). RESULTS: Six of the 16 patients in group A had neurofibromas that were immunopositive for GHR, whereas nine of the 10 patients in group B were immunopositive. CONCLUSIONS: Most patients with NF1 have localised neurofibromas that express GHR. This suggests that GH may play some role in the development of localised neurofibromas in patients with NF1. |
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Authors:
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K S G Cunha; E P Barboza; E C Da Fonseca |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 56 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-29 Completed Date: 2003-11-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: England |
Other Details:
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Languages: eng Pagination: 758-63 Citation Subset: AIM; IM |
Affiliation:
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Federal Fluminense University, Medicine School, Pathology Department, Niterói, Rio de Janeiro, Brazil. karingoncalves@terra.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Female Growth Disorders / complications, drug therapy Growth Hormone / contraindications Humans Immunohistochemistry / methods Male Neurofibroma / chemistry Neurofibromatosis 1 / complications, metabolism* Receptors, Somatotropin / analysis* Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Somatotropin; 0/Tumor Markers, Biological; 9002-72-6/Growth Hormone |
| Comments/Corrections | |
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