Document Detail

Identification of feto-maternal haemorrhage around labour using flow cytometry immunophenotyping.
MedLine Citation:
PMID:  20398998     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the normal range of feto-maternal haemorrhage (FMH) due to labour, and to investigate if the type of delivery might influence the volume of FMH. STUDY DESIGN: In a prospective cohort trial setting we studied 346 women in their 3rd trimester of gestation. Women were classified according to the type of delivery: vaginal, instrumental and caesarean section. Fetal erythrocytes in maternal blood were measured by flow cytometry immunophenotyping using a fluorochrome-conjugated monoclonal antibody against fetal haemoglobin. For each woman, two blood samples were studied; one pre-labour and one post-labour. The difference between FMH values obtained post- and pre-delivery was established as FMH due to delivery. RESULTS: FMH due to labour ranged between <0.01 and 25.19 ml, being <1.15 ml in 96.13% of cases. This value was established as the upper limit of normal FMH due to delivery. No statistical significance was found between the volume of FMH and type of delivery. Analyzing distributions of groups, most data followed a normal distribution, apart from some patients who had higher volume of FMH. Among these patients caesarean sections showed a higher FMH volume, with statistically significant differences between vaginal deliveries and caesarean sections (p=0.001), and between instrumental deliveries and caesarean sections (p=0.008). CONCLUSIONS: FMH due to labour is small. The route of delivery could not be established as a risk factor for FMH but caesarean section increases the risk of suffering a higher amount of transplacental bleeding.
M Uriel; D Subirá; J Plaza; S Castañón; M Cañamares; J Díaz Recasens
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Publication Detail:
Type:  Journal Article     Date:  2010-04-15
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  151     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  20-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Dept Gynecology and Obstetrics, Hospital Quirón, Pozuelo de Alcorcón, Madrid, Spain.
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MeSH Terms
Cesarean Section / adverse effects
Cohort Studies
Delivery, Obstetric / adverse effects
Fetomaternal Transfusion / diagnosis*,  etiology
Flow Cytometry
Labor, Obstetric / blood*
Prospective Studies
Reference Values
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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